Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)
文献类型：期刊论文
| 作者 | Bai, Zhong-Tian1,2; Bai, Bing1,2; Zhu, Jun3; Di, Cui-Xa4; Li, Xun1,2; Zhou, Wen-Ce1,2 |
| 刊名 | ONCOLOGY LETTERS
 |
| 出版日期 | 2018-02-01 |
| 卷号 | 15页码:2049-2056 |
| ISSN号 | 1792-1074 |
| 关键词 | epigenetic modification environmental factor promising drug cancer therapy |
| DOI | 10.3892/ol.2017.7597 |
| 英文摘要 | Carcinogenesis is known to be primarily associated with gene mutations. Recently, increasing evidence has suggested that epigenetic events also serve crucial roles in tumor etiology. Environmental factors, including nutrition, toxicants and ethanol, are involved in carcinogenesis through inducing epigenetic modifications, such as DNA methylation, histone deacetylase and miRNA regulation. Studying epigenetic mechanisms has facilitated the development of early diagnostic strategies and potential therapeutic avenues. Modulation at the epigenetic level, including reversing epigenetic modifications using targeted drugs, has demonstrated promise in cancer therapy. Therefore, identifying novel epigenetic biomarkers and therapeutic targets has potential for the future of cancer therapy. The present review discusses the environmental factors involved in epigenetic modifications and potential drug candidates for cancer therapy. |
| WOS关键词 | HISTONE DEACETYLASE INHIBITOR ; CELL LUNG-CANCER ; VIRUS X PROTEIN ; COLORECTAL-CANCER ; VALPROIC ACID ; TRANSGENERATIONAL INHERITANCE ; HEPATOCELLULAR-CARCINOMA ; ANTITUMOR-ACTIVITY ; SOLID TUMORS ; DISEASE |
| 资助项目 | National Natural Science Fund of China[31570509] ; National Natural Science Fund of China[81702326] ; Gansu Province Science Foundation for Distinguished Young Scholars[1606RJDA317] ; Science and Technology Program of Lanzhou City[2015-3-93] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | SPANDIDOS PUBL LTD |
| WOS记录号 | WOS:000426145100002 |
| 资助机构 | National Natural Science Fund of China ; Gansu Province Science Foundation for Distinguished Young Scholars ; Science and Technology Program of Lanzhou City |
| 源URL | [http://119.78.100.186/handle/113462/47383]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhou, Wen-Ce |
| 作者单位 | 1.Lanzhou Univ, Hosp 1, Key Lab Biotherapy & Regenerat Med, Dept Gen Surg 2, 1 Donggang West St, Lanzhou 730000, Gansu, Peoples R China 2.Lanzhou Univ, Med Coll Canc Ctr, Hepatopancreatobiliary Surg Inst Gansu, Lanzhou 730000, Gansu, Peoples R China 3.Lanzhou Univ, Hosp 1, Pathol Dept, Donggang Branch Courts, Lanzhou 730000, Gansu, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Zhong-Tian,Bai, Bing,Zhu, Jun,et al. Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)[J]. ONCOLOGY LETTERS,2018,15:2049-2056. |
| APA | Bai, Zhong-Tian,Bai, Bing,Zhu, Jun,Di, Cui-Xa,Li, Xun,&Zhou, Wen-Ce.(2018).Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review).ONCOLOGY LETTERS,15,2049-2056. |
| MLA | Bai, Zhong-Tian,et al."Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)".ONCOLOGY LETTERS 15(2018):2049-2056. |
入库方式： OAI收割
来源：近代物理研究所
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