Advances of Mitochondrial Transplantation Therapy for The Mitochondrial Deficiency Diseases
文献类型：期刊论文
| 作者 | Yang Shi-Feng1,2; Sun Chao2,3; Wang Yu-Pei2,3; Chen Yu-Hong2,3; Zhang Qian-Jing2,3; Zhang Hong1,2,3
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| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
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| 出版日期 | 2018-03-01 |
| 卷号 | 45页码:297-304 |
| 关键词 | mitochondrial transplantation mitochondrial dysfunction cerebral ischemia myocardial-ischemia-reperfusion injury tumor |
| ISSN号 | 1000-3282 |
| DOI | 10.16476/j.pibb.2017.0222 |
| 其他题名 | 线粒体移植在治疗线粒体缺陷疾病中的研究进展 |
| 英文摘要 | Mitochondrion are one of the most important organelles in eukaryotic cells, the main function of which is to provide energy for the survival of cells. The abnormal mitochondrial can cause lesions in cells and even organs, and a growing number of diseases have been linked to mitochondrial defects. Mitochondrial transplantation, an intrusive therapy, which isolated the mitochondria from the normal parts of the patient and then inject it into the damaged or absent areas, so that the injured cells can be treated and the organ functions return to normal. As a novel therapeutic strategy, the manner has emerged in the basic research of some diseases, especially in the field of acute myocardial ischemia reperfusion injury, which has been developed to the clinical trial stage. Based on the origin of mitochondria, several feasible methods of mitochondrial transplantation in the experimental phase were summarized. In addition, the protection of cerebral ischemia/induced neuronal injury and tumor therapy by mitochondria transplantation were also introduced. Moreover, the molecular mechanisms of mitochondrial damage and mitochondrial transplantation were discussed, and put forward the research ideas for developing targeted therapeutic biological agents for mitochondrial transplantation. The paper aims to provide a new perspective for curing of mitochondrial deficiency diseases. |
| WOS关键词 | ISCHEMIA-REPERFUSION INJURY ; CYCLIC ADP-RIBOSE ; STEM-CELLS ; CANCER-CELLS ; CALCIUM ; HEART ; ATP ; DYSFUNCTION ; PROTECTS ; RESCUE |
| 资助项目 | National Natural Science Foundation of the Joint Fund Key Projects[U1432248] ; Ministry of Science and Technology Key National R D Projects[2016YFC0904600] ; National Natural Science Foundation of China Youth Fund Project[11505245] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000428323500002 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| 资助机构 | National Natural Science Foundation of the Joint Fund Key Projects ; Ministry of Science and Technology Key National R D Projects ; National Natural Science Foundation of China Youth Fund Project |
| 源URL | [http://119.78.100.186/handle/113462/47557]  |
| 专题 | 中国科学院近代物理研究所 |
| 作者单位 | 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang Shi-Feng,Sun Chao,Wang Yu-Pei,et al. Advances of Mitochondrial Transplantation Therapy for The Mitochondrial Deficiency Diseases[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2018,45:297-304. |
| APA | Yang Shi-Feng,Sun Chao,Wang Yu-Pei,Chen Yu-Hong,Zhang Qian-Jing,&Zhang Hong.(2018).Advances of Mitochondrial Transplantation Therapy for The Mitochondrial Deficiency Diseases.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,45,297-304. |
| MLA | Yang Shi-Feng,et al."Advances of Mitochondrial Transplantation Therapy for The Mitochondrial Deficiency Diseases".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 45(2018):297-304. |
入库方式： OAI收割
来源：近代物理研究所
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