Isoliquiritigenin Enhances Radiosensitivity of HepG2 Cells via Disturbance of Redox Status
文献类型：期刊论文
| 作者 | Sun, Chao1,2,3,4; Zhang, Hong1,2,3 ; Ma, Xiao-fei1,2,3,4; Zhou, Xin1,2,3,4; Gan, Lu1,2,3; Liu, Yuan-yuan1,2,3; Wang, Zhen-hua1,2,3
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| 刊名 | CELL BIOCHEMISTRY AND BIOPHYSICS
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| 出版日期 | 2013-04-01 |
| 卷号 | 65页码:433-444 |
| 关键词 | Radox Status Ros Isoliquiritigenin Radiosensitization Nrf-2 |
| ISSN号 | 1085-9195 |
| DOI | 10.1007/s12013-012-9447-x |
| 文献子类 | Article |
| 英文摘要 | Redox balance plays an important role in the maintenance of cell growth and survival. Disturbance of this equilibrium can alter normal cellular processes. Excessive reactive oxygen species (ROS) are often found in cancer cells. However, cancer cells have an efficient antioxidant system to counteract the increased generation of ROS. This high antioxidant capacity also favors resistance to drugs and radiation. Here, we show that isoliquiritigenin (ISL), a natural antioxidant, effectively decreased ROS in HepG2 cells in a time-dependant manner at 0.5, 1, and 2 h of treatment. The decreased ROS caused redox imbalance and reductive stress. To adapt to this state, nuclear factor erythroid-2-related factor 2, which regulates the antioxidant enzyme system, was significantly decreased. Antioxidant enzymes reached their lowest level at 6 h after ISL treatment. Endogenous ROS were still being generated so after 6 h of ISL treatment, ROS were clearly higher than before ISL treatment, causing redox imbalance in the HepG2 cells which changed from reductive to oxidative stress. At this stage, cells were irradiated with X-rays. The excess ROS induced serious oxidative stress, resulting in radiosensitization. Therefore, we concluded that ISL induced oxidative stress by disturbing the redox status and ultimately enhancing the radiosensitivity of HepG2 cells. |
| WOS关键词 | OXIDATIVE STRESS ; CANCER-CELLS ; DNA-DAMAGE ; IONIZING-RADIATION ; FREE-RADICALS ; ANTICANCER PROPERTIES ; CARCINOMA CELLS ; HUMAN-DISEASE ; IN-VIVO ; MECHANISMS |
| 资助项目 | Western Talent Program of Chinese Academy of Sciences[Y10180XB0] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000316350000014 |
| 出版者 | HUMANA PRESS INC |
| 源URL | [http://119.78.100.186/handle/113462/48119]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Chao,Zhang, Hong,Ma, Xiao-fei,et al. Isoliquiritigenin Enhances Radiosensitivity of HepG2 Cells via Disturbance of Redox Status[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2013,65:433-444. |
| APA | Sun, Chao.,Zhang, Hong.,Ma, Xiao-fei.,Zhou, Xin.,Gan, Lu.,...&Wang, Zhen-hua.(2013).Isoliquiritigenin Enhances Radiosensitivity of HepG2 Cells via Disturbance of Redox Status.CELL BIOCHEMISTRY AND BIOPHYSICS,65,433-444. |
| MLA | Sun, Chao,et al."Isoliquiritigenin Enhances Radiosensitivity of HepG2 Cells via Disturbance of Redox Status".CELL BIOCHEMISTRY AND BIOPHYSICS 65(2013):433-444. |
入库方式： OAI收割
来源：近代物理研究所
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