N-acetylcysteine protect lymphocytes and cytokines against heavy ion irradiation via counteracting the glutamate
文献类型：期刊论文
| 作者 | Xie Yi1,2,3 ; Zhang Hong1,2,3; Wang Yipei4; Liu Yang1,2,3; Chen Yingtai5
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| 刊名 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| 出版日期 | 2013-06-20 |
| 卷号 | 24 |
| 关键词 | N-acetylcysteine C-12(6+) Heavy Ion Dna Damages Oxidative Stress Lymphocytes And Cytokines |
| ISSN号 | 1001-8042 |
| 文献子类 | Article |
| 英文摘要 | We evaluated the protective effect of N-acetylcysteine (NAC) on immunity system irradiated by C-12(6+) ion beam. Kun-Ming mice were whole-body irradiated by C-12(6+) ion at doses of 0, 0.5, 1, 1.5, 2, 2.5 and 3 Gy. The results showed that in saline group, the lymphocytes DNA double-strand breaks (DSBs), maleic dialdehyde, thymocytes number in G(0)/G(1) and apoptosis percentage increased with dose increment, and the levels of interferon-gamma, glutathione, superoxide radical (SOD) and natural killer cells activity decreased with dose increment. However, there were no significant changes in NAC-treated group. The data indicated that pre-treatment with NAC could significantly remove the ROS by counteracting the glutamate, decrease excessive lipid peroxidation reaction and SOD damages, and protect DNA, lymphocytes and cytokines against irradiation. |
| WOS关键词 | INTERFERON-GAMMA ; GLUTATHIONE ; CANCER ; DEPLETION ; IMMUNITY ; BIOLOGY ; MICE |
| 资助项目 | Key Scientific Technology Research Projects of Gansu Province[0702NKDA045] ; Key Scientific Technology Research Projects of Gansu Province[0801NKDA001] |
| WOS研究方向 | Nuclear Science & Technology ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000328921800006 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.186/handle/113462/48133]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 4.Univ Delaware, Dept Chem & Biochem, Newark, DE 19711 USA 5.Chinese Acad Med Sci, Canc Inst & Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie Yi,Zhang Hong,Wang Yipei,et al. N-acetylcysteine protect lymphocytes and cytokines against heavy ion irradiation via counteracting the glutamate[J]. NUCLEAR SCIENCE AND TECHNIQUES,2013,24. |
| APA | Xie Yi,Zhang Hong,Wang Yipei,Liu Yang,&Chen Yingtai.(2013).N-acetylcysteine protect lymphocytes and cytokines against heavy ion irradiation via counteracting the glutamate.NUCLEAR SCIENCE AND TECHNIQUES,24. |
| MLA | Xie Yi,et al."N-acetylcysteine protect lymphocytes and cytokines against heavy ion irradiation via counteracting the glutamate".NUCLEAR SCIENCE AND TECHNIQUES 24(2013). |
入库方式： OAI收割
来源：近代物理研究所
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