Effects of carbon ion beam irradiation on lung injury and pulmonary fibrosis in mice
文献类型：期刊论文
| 作者 | Wu, Zhenhua1,2,3,4 ; Wang, Xinyu4; Yang, Rong5; Liu, Yang1,2,3; Zhao, Weiping1,2,3; Si, Jin1,2,3; Ma, Xiaofei1,2,3; Sun, Chao1,2,3; Liu, Yuanyuan1,2,3; Tan, Yong6
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| 刊名 | EXPERIMENTAL AND THERAPEUTIC MEDICINE
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| 出版日期 | 2013-03-01 |
| 卷号 | 5页码:771-776 |
| 关键词 | Carbon Ion Beam Irradiation Pulmonary Fibrosis Lung Injury Mice |
| ISSN号 | 1792-0981 |
| DOI | 10.3892/etm.2013.881 |
| 文献子类 | Article |
| 英文摘要 | Radiation-induced lung injury is a well-described complication of nuclear accidents, marrow-transplant pretreatment and thoracic radiotherapy. The mechanism is complex and no special therapy for it is available at present. To study radiation pulmonary injury following heavy ion radiotherapy for thoracic tumors, Kunming mice were randomly divided into 4 groups: normal control and 2, 4 and 6 Gy irradiation groups which underwent whole-body exposure to 235 MeV/u C-12(6+) administered at the Heavy Ion Research Facility in Lanzhou (HIRFL). The pathological changes were observed by hematoxylin and eosin staining and the hydroxyproline (HP) content was assessed by spectrophotometry at months 1, 2, 3, 4, 5 and 6 after radiation exposure. In addition, the expression of tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta in the lung tissues was measured. The results showed that, compared with the control group, the lung tissue HP content was increased following irradiation but did not statistically significantly change after 4 months in the 4- and 6-Gy-treated groups. However, in the 2-Gy-treated group, the HP content was markedly increased between months 1 and 4 and decreased after month 4. The extent of the lung injury was significantly increased by the higher radiation dosages but was relieved in the 2 Gy group as the time since irradiation increased. The results also revealed that the levels of TNF-alpha were upregulated and reached a maximum at month 2, but decreased noticeably 2 months later in the experimental groups. The expression of TGF-beta increased markedly in month 4 and was altered little in the 4- and 6-Gy-treated groups but decreased sharply in the 2 Gy irradiation group after month 4. These findings suggest that heavy ion radiotherapy for chest tumors causes lung injury to a certain extent, while there is likely to be little injury to lungs treated with <2 Gy, which provides scientific evidence for the use of heavy ion therapy for thoracic tumors. |
| WOS关键词 | INDUCED OXIDATIVE STRESS ; GROWTH-FACTOR-BETA ; RADIATION PNEUMONITIS ; GENE-EXPRESSION ; EXTRACELLULAR-MATRIX ; NORMAL TISSUE ; MELATONIN ; OVEREXPRESSION ; TGF-BETA-1 ; PARAMETERS |
| 资助项目 | Chinese Academy of Sciences[Y260230XB0] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000315423500020 |
| 出版者 | SPANDIDOS PUBL LTD |
| 源URL | [http://119.78.100.186/handle/113462/48211]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China 4.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China 5.Gansu Prov Med Sci Inst, Lanzhou 730000, Gansu, Peoples R China 6.Shihezi Univ, Coll Pharmaceut Sci, Shihezi 832002, Xinjiang, Peoples R China 7.Yaojie Coal Elect Grp Co, Dept Gastroenterol, Gen Hosp, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Zhenhua,Wang, Xinyu,Yang, Rong,et al. Effects of carbon ion beam irradiation on lung injury and pulmonary fibrosis in mice[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2013,5:771-776. |
| APA | Wu, Zhenhua.,Wang, Xinyu.,Yang, Rong.,Liu, Yang.,Zhao, Weiping.,...&Zhang, Zhongxiang.(2013).Effects of carbon ion beam irradiation on lung injury and pulmonary fibrosis in mice.EXPERIMENTAL AND THERAPEUTIC MEDICINE,5,771-776. |
| MLA | Wu, Zhenhua,et al."Effects of carbon ion beam irradiation on lung injury and pulmonary fibrosis in mice".EXPERIMENTAL AND THERAPEUTIC MEDICINE 5(2013):771-776. |
入库方式： OAI收割
来源：近代物理研究所
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