Mechanisms, function and clinical applications of DNp73
文献类型：期刊论文
| 作者 | Di, Cuixia1,3,4 ; Yang, Lina2; Zhang, Hong1,3,4; Ma, Xiaofei1,3,4; Zhang, Xin1,3,4; Sun, Chao1,3,4; Li, Hongyan1,3,4; Xu, Shuai1,3,4; An, Lizhe2; Li, Xun5
|
| 刊名 | CELL CYCLE
 |
| 出版日期 | 2013-06-15 |
| 卷号 | 12页码:1861-1867 |
| 关键词 | Dnp73 Alternative Splicing Apoptosis Cancer Chemosensitivity Radiotherapy Tumorigenesis |
| ISSN号 | 1538-4101 |
| DOI | 10.4161/cc.24967 |
| 文献子类 | Article |
| 英文摘要 | p73, has two distinct promoters, which allow the formation of two protein isoforms: full-length transactivating (TA) p73 and an N-terminally truncated p73 species (referred to as DNp73) that lacks the N-terminal transactivating domain. Although the exact cellular function of DNp73 is unclear, the high expression levels of the genes have been observed in a variety of human cancers and cancer cell lines and have been connected to pro-tumor activities. Hence the aim of this review is to summarize DNp73 expression status in cancer in the current literature. Furthermore, we also focused on recent findings of DNp73 related to the biological functions from apoptosis, chemosensitivity, radiosensitibity, differentiation, development, etc. Thus this review highlights the significance of DNp73 as a marker for disease severity in patients and as target for cancer therapy. |
| WOS关键词 | CERVICAL-CANCER CELLS ; P53 FAMILY ; TUMOR-SUPPRESSOR ; IN-VIVO ; OVARIAN-CANCER ; LUNG-CANCER ; DNA-DAMAGE ; HEPATOCELLULAR-CARCINOMA ; DELTA-NP73 EXPRESSION ; NEURONAL SURVIVAL |
| 资助项目 | Western Talent Program of Chinese Academy of Sciences[Y260230XB0] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000323170200017 |
| 出版者 | LANDES BIOSCIENCE |
| 源URL | [http://119.78.100.186/handle/113462/48217]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou, Peoples R China 2.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China 4.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou, Peoples R China 5.Lanzhou Univ, Hosp 1, Dept Gen Surg 2, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Di, Cuixia,Yang, Lina,Zhang, Hong,et al. Mechanisms, function and clinical applications of DNp73[J]. CELL CYCLE,2013,12:1861-1867. |
| APA | Di, Cuixia.,Yang, Lina.,Zhang, Hong.,Ma, Xiaofei.,Zhang, Xin.,...&Bai, Zhongtian.(2013).Mechanisms, function and clinical applications of DNp73.CELL CYCLE,12,1861-1867. |
| MLA | Di, Cuixia,et al."Mechanisms, function and clinical applications of DNp73".CELL CYCLE 12(2013):1861-1867. |
入库方式： OAI收割
来源：近代物理研究所
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