Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice
文献类型：期刊论文
| 作者 | Liu Yang1,2,3 ; Zhang Luwei1,2,3; Zhang Hong1,2,3; Wu Zhenhua1,2,3; Wang Zhenhua1,2,3; Wang Yibo4; Li Hongyan1,2,3; Ma Xiaofei1,2,3; Xie Yi1,2,3
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| 刊名 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| 出版日期 | 2013-12-01 |
| 卷号 | 24 |
| 关键词 | Stimulated Microgravity High-let Irradiation Carbon Ion Mouse Testis |
| ISSN号 | 1001-8042 |
| 文献子类 | Article |
| 英文摘要 | This study investigated the impact of simulated microgravity on acute injury induced by low doses of carbon ions in male reproductive organs of mice, and determined alterations in spermatogenic function and expression levels of apoptotic factors in mice following exposure to acute irradiation after 7 days of simulated microgravity. The results demonstrated that significant reductions in spermatozoa, primary spermatocytes and spermatogonia, and increased globular cells in seminiferous tubule and pro-apoptotic proteins were observed in the group exposed to over 0.4 Gy irradiation. Collectively, the data suggest that lesions inflicted by simulated microgravity are not markedly modified by lower doses of irradiation (0.2 Gy) in mottle testis compared to the control group. However, testicular impairments were markedly evident in the group exposed to higher doses of carbon ions plus simulated microgravity, which may be due at least in part to elevated apoptosis initiated by the mitochondrial apoptosis pathway in germ cells. |
| WOS关键词 | RAT TESTIS ; SEMINIFEROUS TUBULES ; SKELETAL-MUSCLE ; MOUSE TESTIS ; RADIATION ; SPACE ; CELLS ; SPERMATOCYTES ; SPERMATOGONIA ; IRRADIATION |
| 资助项目 | National Natural Science Foundation of China[10835011] ; National Natural Science Foundation of China[10675151] ; National Natural Science Foundation of China[41161058] ; National Natural Science Foundation of China[31060065] ; National Natural Science Foundation of China[10805064] |
| WOS研究方向 | Nuclear Science & Technology ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000333230600011 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.186/handle/113462/48287]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 4.Tianshui Normal Univ, Coll Life Sci & Chem, Tianshui 741000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Yang,Zhang Luwei,Zhang Hong,et al. Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice[J]. NUCLEAR SCIENCE AND TECHNIQUES,2013,24. |
| APA | Liu Yang.,Zhang Luwei.,Zhang Hong.,Wu Zhenhua.,Wang Zhenhua.,...&Xie Yi.(2013).Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice.NUCLEAR SCIENCE AND TECHNIQUES,24. |
| MLA | Liu Yang,et al."Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice".NUCLEAR SCIENCE AND TECHNIQUES 24(2013). |
入库方式： OAI收割
来源：近代物理研究所
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