Monocytic Differentiation of K562 Cells Induced by Proanthocyanidins from Grape Seeds
文献类型：期刊论文
| 作者 | Wang, Min3,4; Wang, Li3; Pan, Xiao-Jing5; Zhang, Hong1,2
|
| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 35页码:129-135 |
| 关键词 | Grape Seeds Procyanidins Monocytic Differentiation Intracellular Reactive Oxygen Species K562 Cells G1 Arrest |
| ISSN号 | 0253-6269 |
| DOI | 10.1007/s12272-012-0114-y |
| 文献子类 | Article |
| 英文摘要 | Grape seeds procyanidins can inhibit the proliferation of some cancer cell lines and have strong antioxidant activity. The purpose of this study was to investigate whether grape seeds procyanidins affect the proliferation and redifferentiation in K562 cells. The sulforhodamine B colorimetric assay and trypan blue staining were used to measure cell proliferation and survival. Morphological changes, NBT reductive activity, and surface antigens were used to detect redifferentiation of K562 cells. Intracellular reactive oxygen species (iROS) were detected by a fluorescent probe. Grape seeds procyanidins inhibited cell proliferation but the treatment did not appreciably increase lethality. After treatment with grape seeds procyanidins, a typical differentiated morphology was observed. The positive rate of CD11b and CD14 cells and NBT reductive activities increased significantly. As antioxidants, grape seeds procyanidins can induce arrest in the phase G1 and decrease iROS formation. All results indicate that the antioxidant grape seeds procyanidins are likely to induce monocytic differentiation in leukemia cells, mostly through decreasing iROS formation and inducing phase G1 arrest. |
| WOS关键词 | BREAST-CARCINOMA CELLS ; SAFETY EVALUATION ; NITRIC-OXIDE ; EXTRACT ; APOPTOSIS ; DOXORUBICIN ; INDUCTION ; THERAPY ; CANCER |
| 资助项目 | Lanzhou University[lzujc200917] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000299757300016 |
| 出版者 | PHARMACEUTICAL SOC KOREA |
| 源URL | [http://119.78.100.186/handle/113462/48591]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China 4.Lanzhou Univ, Sch Basic Med, Lanzhou 730000, Peoples R China 5.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Min,Wang, Li,Pan, Xiao-Jing,et al. Monocytic Differentiation of K562 Cells Induced by Proanthocyanidins from Grape Seeds[J]. ARCHIVES OF PHARMACAL RESEARCH,2012,35:129-135. |
| APA | Wang, Min,Wang, Li,Pan, Xiao-Jing,&Zhang, Hong.(2012).Monocytic Differentiation of K562 Cells Induced by Proanthocyanidins from Grape Seeds.ARCHIVES OF PHARMACAL RESEARCH,35,129-135. |
| MLA | Wang, Min,et al."Monocytic Differentiation of K562 Cells Induced by Proanthocyanidins from Grape Seeds".ARCHIVES OF PHARMACAL RESEARCH 35(2012):129-135. |
入库方式： OAI收割
来源：近代物理研究所
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