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A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer

文献类型：期刊论文

作者Li, Ning1,2,7; Kaur, Sippy5,6; Greshock, Joel3; Lassus, Heini5,6; Zhong, Xiaomin1,2; Wang, Yanling1,2; Leminen, Arto5,6; Shao, Zhongjun1,2; Hu, Xiaowen1,2; Liang, Shun1,2
刊名CANCER RESEARCH
出版日期2012
卷号72页码:154-164
ISSN号0008-5472
DOI10.1158/0008-5472.CAN-11-2484
文献子类Article
英文摘要Oncomirs are microRNAs (miRNA) that acts as oncogenes or tumor suppressor genes. Efficient identification of oncomirs remains a challenge. Here we report a novel, clinically guided genetic screening approach for the identification of oncomirs, identifying mir-30d through this strategy. mir-30d regulates tumor cell proliferation, apoptosis, senescence, and migration. The chromosomal locus harboring mir-30d was amplified in more than 30% of multiple types of human solid tumors (n=1,283). Importantly, higher levels of mir-30d expression were associated significantly with poor clinical outcomes in ovarian cancer patients (n-330, P-0.0016). Mechanistic investigations suggested that mir-30d regulates a large number of cancer-associated genes, including the apoptotic caspase CASP3. The guided genetic screening approach validated by this study offers a powerful tool to identify oncomirs that may have utility as biomarkers or targets for drug development. Cancer Res; 72(1); 154-64. (C) 2011 AACR.
WOS关键词CHRONIC LYMPHOCYTIC-LEUKEMIA ; MICRORNA SIGNATURES ; TUMOR-SUPPRESSOR ; GENE-EXPRESSION ; LUNG-CANCER ; C-ELEGANS ; RNAS ; METASTASIS ; CELLS ; INVASION
资助项目Ovarian Cancer SPORE[P50-CA83638-7951]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000298755600016
出版者AMER ASSOC CANCER RESEARCH
源URL[http://119.78.100.186/handle/113462/48599]  
专题中国科学院近代物理研究所
通讯作者Zhang, Lin
作者单位1.Univ Penn, Ovarian Canc Res Ctr, Philadelphia, PA 19104 USA
2.Univ Penn, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA
3.Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
4.Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA
5.Univ Helsinki, Dept Obstet & Gynecol & Pathol, FIN-00014 Helsinki, Finland
6.Helsinki Univ Cent Hosp, Helsinki, Finland
7.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China
8.Univ Turin, Dept Obstet & Gynecol, Turin, Italy
推荐引用方式
GB/T 7714		 Li, Ning,Kaur, Sippy,Greshock, Joel,et al. A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer[J]. CANCER RESEARCH,2012,72:154-164.
APA Li, Ning.,Kaur, Sippy.,Greshock, Joel.,Lassus, Heini.,Zhong, Xiaomin.,...&Zhang, Lin.(2012).A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer.CANCER RESEARCH,72,154-164.
MLA Li, Ning,et al."A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer".CANCER RESEARCH 72(2012):154-164.

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来源：近代物理研究所

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