Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells
文献类型：期刊论文
| 作者 | Sun, Chao1,2,3; Wang, Zhenhua1,2,4 ; Zheng, Qiusheng4; Zhang, Hong1,2
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| 刊名 | PHYTOMEDICINE
 |
| 出版日期 | 2012-02-15 |
| 卷号 | 19页码:355-363 |
| 关键词 | Salidroside Invasion Metastasis Ht1080 Cells Reactive Oxygen Species |
| ISSN号 | 0944-7113 |
| DOI | 10.1016/j.phymed.2011.09.070 |
| 文献子类 | Article |
| 英文摘要 | Oxidative stress plays an important role in tumorigenesis and metastasis. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L. shows potent antioxidant property. Here we investigated the inhibitory effects of salidroside on tumor metastasis in human fibrosarcoma HT1080 cells in vitro. The results indicated that salidroside significantly reduced wound closure areas of HT1080 cells, inhibited HT1080 cells invasion into Matrigel-coated membranes, suppressed matrix metalloproteinases (MMP-2 and MMP-9) activity, and increased tissue inhibitor of metalloproteinase-2 (TIMP-2) expression in a dose-dependent manner in HT1080 cells. Salidroside treatment upregulated the E-cadherin expression, while downregulated the expression of beta 1-integrin. As an antioxidant, salidroside inhibited the intracellular reactive oxygen species (ROS) formation in a dose-dependent manner. The results also showed that salidroside could inhibit the activation of protein kinase C (PKC) and the phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) in a dose-dependent manner. In conclusion, these results suggest that salidroside inhibits tumor cells metastasis, which may due to its interfere in the intracellular excess ROS thereby down-regulated the ROS-PKC-ERK1/2 signaling pathway. (C) 2011 Elsevier GmbH. All rights reserved. |
| WOS关键词 | SIGNAL-REGULATED KINASE ; CANCER METASTASIS ; OXIDATIVE STRESS ; INTEGRIN EXPRESSION ; ADHESION MOLECULES ; HYDROGEN-PEROXIDE ; DEPENDENT PATHWAY ; TUMOR PROGRESSION ; INDUCED APOPTOSIS ; EPITHELIAL-CELLS |
| 资助项目 | China Postdoctoral Science Foundation[200902313] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000302928400025 |
| 出版者 | ELSEVIER GMBH, URBAN & FISCHER VERLAG |
| 源URL | [http://119.78.100.186/handle/113462/48797]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Wang, Zhenhua |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 4.Shihezi Univ, Key Lab Xinjiang Endem Phytomed Resources, Minist Educ, Sch Pharm, Shihezi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Chao,Wang, Zhenhua,Zheng, Qiusheng,et al. Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells[J]. PHYTOMEDICINE,2012,19:355-363. |
| APA | Sun, Chao,Wang, Zhenhua,Zheng, Qiusheng,&Zhang, Hong.(2012).Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells.PHYTOMEDICINE,19,355-363. |
| MLA | Sun, Chao,et al."Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells".PHYTOMEDICINE 19(2012):355-363. |
入库方式： OAI收割
来源：近代物理研究所
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