Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1
文献类型：期刊论文
| 作者 | Huang, Shuangsheng1; Yang, Ninggang2; Liu, Yuanyuan3 ; Gao, Jing1; Huang, Tao1; Hu, Lamei4; Zhao, Jin1; Li, Yongquan1; Li, Caili1; Zhang, Xiaosu1
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
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| 出版日期 | 2012-12-01 |
| 卷号 | 30页码:1410-1416 |
| 关键词 | Grape Seed Proanthocyanidin Colon Cancer Angiogenesis Vascular Endothelial Growth Factor Angiopoietin 1 Reactive Oxygen Species |
| ISSN号 | 1107-3756 |
| DOI | 10.3892/ijmm.2012.1147 |
| 文献子类 | Article |
| 英文摘要 | Tumor cells trigger angiogenesis through overexpression of various angiogenic factors including vascular endothelial growth factor (VEGF) and angiopoietin 1 (Ang1). Therefore, inhibition of the expression of both VEGF and Ang1, the initial step of tumor angiogenesis, is a promising strategy for cancer chemoprevention and therapy. Grape seed proanthocyanidins (GSPs) are widely consumed dietary supplements that have antitumor activity. Due to their polymeric structure, GSPs are poorly absorbed along the gastrointestinal tract and can reach the colon at high concentrations, allowing these chemicals to act as chemopreventive agents for colon cancer. In the present study, we found that GSPs inhibited colon tumor-induced angiogenesis and, thus, the growth of colon tumor xenografts on the chick chorioallantoic membranes. The mechanisms of their action were related to inhibiting the expression of both VEGF and Ang1 through scavenging reactive oxygen species. Previous studies have demonstrated that the chemopreventive effects of GSPs on colon cancer are associated with their growth inhibitory and apoptosis-inducing effects. Our results demonstrate another mechanism by which GSPs inhibit colon tumor growth, which will be helpful for developing GSPs as a pharmacologically safe angiopreventive agent against colorectal cancer. |
| WOS关键词 | COLORECTAL-CARCINOMA CELLS ; ENDOTHELIAL GROWTH-FACTOR ; TUMOR-GROWTH ; COCOA PROCYANIDINS ; IN-VITRO ; EXTRACT ; APOPTOSIS ; DIETARY ; TUMORIGENESIS ; MECHANISMS |
| 资助项目 | Scientific Research Innovation Team of Northwest University for Nationalities[BMUCXTD-2011-1] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000311771400021 |
| 出版者 | SPANDIDOS PUBL LTD |
| 源URL | [http://119.78.100.186/handle/113462/48947]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Huang, Shuangsheng |
| 作者单位 | 1.NW Univ Nationalities, Coll Med, Lanzhou 730030, Gansu, Peoples R China 2.Lanzhou First Peoples Hosp, Dept Urol, Lanzhou, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 4.Lanzhou Univ, Sch Basic Med Sci, Inst Pharmacol, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Shuangsheng,Yang, Ninggang,Liu, Yuanyuan,et al. Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2012,30:1410-1416. |
| APA | Huang, Shuangsheng.,Yang, Ninggang.,Liu, Yuanyuan.,Gao, Jing.,Huang, Tao.,...&Zhang, Xiaosu.(2012).Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,30,1410-1416. |
| MLA | Huang, Shuangsheng,et al."Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 30(2012):1410-1416. |
入库方式： OAI收割
来源：近代物理研究所
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