Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietin signaling
文献类型：期刊论文
| 作者 | Huang, Shuangsheng1; Yang, Ninggang2; Liu, Yuanyuan3 ; Hu, Lamei4; Zhao, Jin1; Gao, Jing1; Li, Yongquan1; Li, Caili1; Zhang, Xiaosu1; Huang, Tao1
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| 刊名 | NUTRITION RESEARCH
 |
| 出版日期 | 2012-07-01 |
| 卷号 | 32页码:530-536 |
| 关键词 | Grape Seed Proanthocyanidins Angiogenesis Vegfr2 Tie2 Hmec-1 Endothelial Cells Chick Chorioallantoic Membrane |
| ISSN号 | 0271-5317 |
| DOI | 10.1016/j.nutres.2012.05.012 |
| 文献子类 | Article |
| 英文摘要 | Vascular endothelial growth factor (VEGF)/VEGF receptor 2 and angiopoietin 1/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2 signaling pathways regulate different, but complementary, aspects of blood vessel growth in tumors. Simultaneous inhibition of both pathways not only exhibits additive antiangiogenic effects but also overcomes the resistance to anti-VEGF therapy. Grape seed proanthocyanidins (GSPs) are widely consumed dietary supplements with antiangiogenic activity. However, the molecular mechanisms underlying their antiangiogenic action have not been fully understood. We hypothesized that GSPs modulate multiple signaling pathways to exhibit antiangiogenic effects. In the present study, we aimed to test this hypothesis by examining the effects of GSPs on human microvascular endothelial cell-1 and chick chorioallantoic membrane. Our results showed that GSPs inhibited the migration, matrix metalloproteinase-2 and -9 secretion, and tube formation of human microvascular endothelial cell-1 in vitro in a dose-dependent manner. In addition, chick chorioallantoic membrane angiogenesis assay showed that GSPs inhibited neovascularization in a dose-dependent manner. Furthermore, we demonstrated that GSPs inhibited the phosphorylation of VEGF receptor 2 and tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2 as well as downstream signaling component extracellular signal-regulated kinase 1/2. In summary, these data suggest that GSPs inhibit both VEGF and angiopoietin 1 signaling to execute the antiangiogenic effects and indicate that GSPs could be developed as a pharmacologically safe chemopreventive agent against cancer. (C) 2012 Elsevier Inc. All rights reserved. |
| WOS关键词 | TUMOR-GROWTH ; CANCER ; CELLS ; VEGF ; EXTRACT ; KINASE |
| 资助项目 | Scientific Research Innovation Team of Northwest University for Nationalities[XBMUCXTD-2011-1] |
| WOS研究方向 | Nutrition & Dietetics |
| 语种 | 英语 |
| WOS记录号 | WOS:000307917100008 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.186/handle/113462/49031]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Huang, Shuangsheng |
| 作者单位 | 1.NW Univ Nationalities, Coll Med, Lanzhou 730030, Peoples R China 2.Lanzhou First Peoples Hosp, Dept Urol, Lanzhou 730030, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 4.Lanzhou Univ, Sch Basic Med Sci, Inst Pharmacol, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Shuangsheng,Yang, Ninggang,Liu, Yuanyuan,et al. Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietin signaling[J]. NUTRITION RESEARCH,2012,32:530-536. |
| APA | Huang, Shuangsheng.,Yang, Ninggang.,Liu, Yuanyuan.,Hu, Lamei.,Zhao, Jin.,...&Huang, Tao.(2012).Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietin signaling.NUTRITION RESEARCH,32,530-536. |
| MLA | Huang, Shuangsheng,et al."Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietin signaling".NUTRITION RESEARCH 32(2012):530-536. |
入库方式： OAI收割
来源：近代物理研究所
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