Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF
文献类型：期刊论文
| 作者 | Liu, Yang1,2,3 ; Liu, Yuanyuan1,2,3; Sun, Chao1,2,3; Gan, Lu1,2,3; Zhang, Luwei1,2,3; Mao, Aihong1,2,3,4; Du, Yuting5; Zhou, Rong1,2,3; Zhang, Hong1,2,3
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| 刊名 | PLOS ONE
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| 出版日期 | 2014-06-03 |
| 卷号 | 9 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0098448 |
| 文献子类 | Article |
| 英文摘要 | This study evaluated the effects of carbon ion and X-ray radiation and the tumor microenvironment on the migration of glioma and endothelial cells, a key process in tumorigenesis and angiogenesis during cancer progression. C6 glioma and human microvascular endothelial cells were treated with conditioned medium from cultures of glioma cells irradiated at a range of doses and the migration of both cell types, tube formation by endothelial cells, as well as the expression and secretion of migration-related proteins were evaluated. Exposure to X-ray radiation-conditioned medium induced dose-dependent increases in cell migration and tube formation, which were accompanied by an upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-2 and -9 expression. However, glioma cells treated with conditioned medium of cells irradiated at a carbon ion dose of 4.0 Gy showed a marked decrease in migratory potential and VEGF secretion relative to non-irradiated cells. The application of recombinant VEGF165 stimulated migration in glioma and endothelial cells, which was associated with increased FAK phosphorylation at Tyr861, suggesting that the suppression of cell migration by carbon ion radiation could be via VEGF-activated FAK signaling. Taken together, these findings indicate that carbon ion may be superior to X-ray radiation for inhibiting tumorigenesis and angiogenesis through modulation of VEGF level in the glioma microenvironment. |
| WOS关键词 | FOCAL ADHESION KINASE ; IONIZING-RADIATION ; MALIGNANT GLIOMA ; IN-VITRO ; GENE ; ANGIOGENESIS ; RADIOTHERAPY ; IRRADIATION ; INVASION ; FAK |
| 资助项目 | Scientific Technology Research Projects of Gansu Province[0702NKDA045] ; Scientific Technology Research Projects of Gansu Province[0806RJYA020] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| WOS记录号 | WOS:000336911400052 |
| 源URL | [http://119.78.100.186/handle/113462/49283]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 5.Lanzhou Univ, Hosp Stomatol, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yang,Liu, Yuanyuan,Sun, Chao,et al. Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF[J]. PLOS ONE,2014,9. |
| APA | Liu, Yang.,Liu, Yuanyuan.,Sun, Chao.,Gan, Lu.,Zhang, Luwei.,...&Zhang, Hong.(2014).Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF.PLOS ONE,9. |
| MLA | Liu, Yang,et al."Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF".PLOS ONE 9(2014). |
入库方式： OAI收割
来源：近代物理研究所
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