GANRA-5 protects both cultured cells and mice from various radiation types by functioning as a free radical scavenger
文献类型：期刊论文
| 作者 | Pei, H.1,2; Chen, W.1; Hu, W.1; Zhu, M.1; Liu, T.1; Wang, J.1; Zhou, G.1 |
| 刊名 | FREE RADICAL RESEARCH
 |
| 出版日期 | 2014-06-01 |
| 卷号 | 48页码:670-678 |
| 关键词 | Radio-protectors Ganra-5 Reactive Oxygen Species Free Radicals Radiation |
| ISSN号 | 1071-5762 |
| DOI | 10.3109/10715762.2014.898843 |
| 文献子类 | Article |
| 英文摘要 | The radio-protective effects of the oxazolone derivative chemical compound 4-(4-methoxy-3-methoxyphenyl-methyl)-2-phenyl-5( 4H)-oxazolone (GANRA-5) against different types of radiation including X-rays, carbon ion beams, microwaves and ultraviolet light (UV) were studied. Cell proliferation/cytotoxicity assay and colony-forming assay were conducted to evaluate the toxicity of GANRA-5. To test its influence on the induction of double-stranded break (DSB) formation and genomic instability,. H2AX focus-forming assay as well as cytokinesis-block micronucleus assay was utilized. Our results indicate that GANRA-5 exhibits low toxicity, while providing high radio-protective effects for MRC-5 cells against different types of radiation. We also found that GANRA-5 acts as a free radical scavenger. Our animal studies provided evidence that GANRA-5 significantly increases the survival rate of mice after X-ray irradiation. Analyses of hemogram, visceral index and detection of superoxide dismutase (SOD) and malondialdehyde (MDA) in the viscera indicate both low toxicity of GANRA-5, combined with its ability to shield radiation risk. In conclusion, our results suggest that GANRA-5 has the potential to be used as a safe and efficient radio-protectant. |
| WOS关键词 | IONIZING-RADIATION ; INDUCED APOPTOSIS ; GAMMA-H2AX FOCI ; PROLIFERATION ; ASSAY ; HEPATOCYTES ; EXPOSURE ; SURVIVAL ; INJURY |
| 资助项目 | National Natural Science Foundations of China awarded[11335011] ; National Natural Science Foundations of China awarded[31370846] ; National Natural Science Foundations of China awarded[10979062] ; National Natural Science Foundations of China awarded[U1232125] ; National Natural Science Foundations of China awarded[31270895] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000336044800005 |
| 出版者 | INFORMA HEALTHCARE |
| 源URL | [http://119.78.100.186/handle/113462/49305]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhou, G. |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Space Radiobiol, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pei, H.,Chen, W.,Hu, W.,et al. GANRA-5 protects both cultured cells and mice from various radiation types by functioning as a free radical scavenger[J]. FREE RADICAL RESEARCH,2014,48:670-678. |
| APA | Pei, H..,Chen, W..,Hu, W..,Zhu, M..,Liu, T..,...&Zhou, G..(2014).GANRA-5 protects both cultured cells and mice from various radiation types by functioning as a free radical scavenger.FREE RADICAL RESEARCH,48,670-678. |
| MLA | Pei, H.,et al."GANRA-5 protects both cultured cells and mice from various radiation types by functioning as a free radical scavenger".FREE RADICAL RESEARCH 48(2014):670-678. |
入库方式： OAI收割
来源：近代物理研究所
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