Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis
文献类型：期刊论文
| 作者 | Yuan, Xuan1; Li, Tao1; Xiao, Erlong1; Zhao, Hong2; Li, Yongqian1; Fu, Shengjun1; Gan, Lu4 ; Wang, Zhenhua3; Zheng, Qiusheng2,3; Wang, Zhiping1
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| 刊名 | FOOD AND CHEMICAL TOXICOLOGY
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| 出版日期 | 2014-03-01 |
| 卷号 | 65页码:242-251 |
| 关键词 | Licochalcone b Bladder Cancer s Phase Arrest Apoptosis |
| ISSN号 | 0278-6915 |
| DOI | 10.1016/j.fct.2013.12.030 |
| 文献子类 | Article |
| 英文摘要 | To examine the mechanisms by which licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in M849 (murine bladder cancer cell line) tumor model. Exposure of T24 or EJ cells to LCB significantly inhibited cell lines proliferation in a concentration-dependent and time-dependent manner, and resulted in S phase arrest in T24 or EJ cells, respectively. LCB treatment decreased the expression of cyclin A, cyclin-dependent kinase (CDK1 and CDK2) mRNA, cell division cycle 25 (Cdc25A and Cdc25B) protein. In addition, LCB treatment down-regulated Bcl-2 and survivin expression, enhanced Bax expression, activated caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP) protein. Consistently, the tumorigenicity of LCB-treated MB49 cells was limited significantly by using the colony formation assay in vitro and the MB49 tumor model performed in C57BL/6 mice in vivo. These findings provide support for the use of LCB in chemoprevention and bladder cancer therapy. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CHALCONE FLAVOKAWAIN ; ROS GENERATION ; KAVA CHALCONE ; TUMOR-GROWTH ; IN-VITRO ; PROTEIN ; THERAPY ; PATHWAY ; CDC25B ; PHASE |
| 资助项目 | International Cooperation Projects[2012BC001] |
| WOS研究方向 | Food Science & Technology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000332500500031 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.186/handle/113462/49335]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zheng, Qiusheng |
| 作者单位 | 1.Lanzhou Univ, Inst Urol, Hosp 2, Lanzhou 730030, Peoples R China 2.Shihezi Univ, Key Lab Xinjiang Endem Phytomed Resources, Minist Educ, Sch Pharm, Shihezi 832002, Peoples R China 3.Yantai Univ, Sch Life Sci, Yantai 264000, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Xuan,Li, Tao,Xiao, Erlong,et al. Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis[J]. FOOD AND CHEMICAL TOXICOLOGY,2014,65:242-251. |
| APA | Yuan, Xuan.,Li, Tao.,Xiao, Erlong.,Zhao, Hong.,Li, Yongqian.,...&Wang, Zhiping.(2014).Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis.FOOD AND CHEMICAL TOXICOLOGY,65,242-251. |
| MLA | Yuan, Xuan,et al."Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis".FOOD AND CHEMICAL TOXICOLOGY 65(2014):242-251. |
入库方式： OAI收割
来源：近代物理研究所
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