The combined effects of X-ray radiation and hindlimb suspension on bone loss
文献类型：期刊论文
| 作者 | Xu, Dan1; Zhao, Xin2; Li, Yi2; Ji, Yinli3; Zhang, Jiangyan4; Wang, Jufang1; Xie, Xiaodong2; Zhou, Guangming1 |
| 刊名 | JOURNAL OF RADIATION RESEARCH
 |
| 出版日期 | 2014-07-01 |
| 卷号 | 55页码:720-725 |
| 关键词 | Bone Loss Hindlimb Suspension X-ray Radiation Trabecular Parameters |
| ISSN号 | 0449-3060 |
| DOI | 10.1093/jrr/rru014 |
| 文献子类 | Article |
| 英文摘要 | Outer space is a complex environment with various phenomena that negatively affect bone metabolism, including microgravity and highly energized ionizing radiation. In the present study, we used four groups of male Wistar rats treated with or without four-week hindlimb suspension after 4 Gy of X-rays to test whether there is a combined effect for hindlimb suspension and X-ray radiation. We tested trabecular parameters and some cytokines of the bone as leading indicators of bone metabolism. The results showed that hindlimb suspension and X-ray radiation could cause a significant increase in bone loss. Hindlimb suspension caused a 56.6% bone loss (P = 0.036), while X-ray radiation caused a 30.7% (P = 0.041) bone loss when compared with the control group. The combined factors of hindlimb suspension and X-rays exerted a combined effect on bone mass, with a reduction of 64.8% (P = 0.003). |
| WOS关键词 | LONG-DURATION SPACEFLIGHT ; TRABECULAR BONE ; SPACE-FLIGHT ; MODEL ; CELLS ; OSTEOCLASTOGENESIS ; MICROGRAVITY ; OSTEOPOROSIS ; IRRADIATION ; MICE |
| 资助项目 | National Natural Science Foundation of China[81272454] ; National Natural Science Foundation of China[31070763] ; National Natural Science Foundation of China[11335011] ; National Natural Science Foundation of China[31370846] ; National Natural Science Foundation of China[U1232125] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000339920200013 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.186/handle/113462/49459]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Xie, Xiaodong |
| 作者单位 | 1.Chinese Acad Sci, Dept Space Radiobiol, Key Lab Heavy Ion Radiat Biol & Med, Inst Modern Phys, Lanzhou, Peoples R China 2.Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China 3.Gansu Hualing Biotechnol Res Ctr, Lanzhou 730000, Peoples R China 4.Lanzhou Univ, Inst Pathol, Sch Basic Med Sci, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Dan,Zhao, Xin,Li, Yi,et al. The combined effects of X-ray radiation and hindlimb suspension on bone loss[J]. JOURNAL OF RADIATION RESEARCH,2014,55:720-725. |
| APA | Xu, Dan.,Zhao, Xin.,Li, Yi.,Ji, Yinli.,Zhang, Jiangyan.,...&Zhou, Guangming.(2014).The combined effects of X-ray radiation and hindlimb suspension on bone loss.JOURNAL OF RADIATION RESEARCH,55,720-725. |
| MLA | Xu, Dan,et al."The combined effects of X-ray radiation and hindlimb suspension on bone loss".JOURNAL OF RADIATION RESEARCH 55(2014):720-725. |
入库方式： OAI收割
来源：近代物理研究所
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