Investigation of strontium accumulation on ovariectomized Sprague-Dawley rat tibia by micro-PIXE
文献类型：期刊论文
| 作者 | Li, X.1; Li, Y.1; Jin, W.2; Zheng, Y.1; Rong, C.1; Lyu, H.1; Shen, H.1 |
| 刊名 | NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
 |
| 出版日期 | 2014-08-01 |
| 卷号 | 332页码:321-325 |
| 关键词 | Micro-pixe Strontium Ranelate Strontium Chloride Osteoporosis |
| ISSN号 | 0168-583X |
| DOI | 10.1016/j.nimb.2014.02.087 |
| 文献子类 | Article |
| 英文摘要 | Strontium ranelate is a newly developed drug effective in osteoporosis treatment by depressing bone resorption and maintaining bone formation. Strontium accumulation and distribution are determined in bones of rat after strontium ranelate administration by using micro-PIXE. The investigated rats are divided into four groups: (A) control, (B) ovariectomized, (C) ovariectomized followed with strontium chloride, (D) ovariectomized followed with strontium ranelate. It was found that strontium ranelate would result in increasing trabecular volume and decreasing bone resorption to treat osteoporosis. There are similar contours of calcium and strontium in two-dimensional images, while the strontium is not evenly distributed in the bone. It supports the conclusion that strontium has an affinity for bone and it is capable of replacing calcium atoms as a part of the strontium mechanism in the osteoporosis treatment. The results related to biochemistry are also discussed. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS关键词 | BONE MINERALIZATION DENSITY ; CALCIUM-SENSING RECEPTOR ; RESORPTION IN-VITRO ; OSTEOBLAST DIFFERENTIATION ; POSTMENOPAUSAL OSTEOPOROSIS ; PARATHYROID-HORMONE ; RANELATE TREATMENT ; FLUORIDE TREATMENT ; CELL REPLICATION ; SODIUM-FLUORIDE |
| 语种 | 英语 |
| WOS记录号 | WOS:000339131200071 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.186/handle/113462/49591]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Shen, H. |
| 作者单位 | 1.Fudan Univ, Inst Modern Phys, Shanghai 200433, Peoples R China 2.Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, X.,Li, Y.,Jin, W.,et al. Investigation of strontium accumulation on ovariectomized Sprague-Dawley rat tibia by micro-PIXE[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,2014,332:321-325. |
| APA | Li, X..,Li, Y..,Jin, W..,Zheng, Y..,Rong, C..,...&Shen, H..(2014).Investigation of strontium accumulation on ovariectomized Sprague-Dawley rat tibia by micro-PIXE.NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,332,321-325. |
| MLA | Li, X.,et al."Investigation of strontium accumulation on ovariectomized Sprague-Dawley rat tibia by micro-PIXE".NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 332(2014):321-325. |
入库方式： OAI收割
来源：近代物理研究所
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