Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells
文献类型：期刊论文
| 作者 | Liu, Yuanyuan1,2,3 ; Liu, Yang1,2,3; Zhang, Hong1,2,3; Sun, Chao1,2,3; Zhao, Qiuyue1,2,3; Di, Cixia1,2,3; Li, Hongyan1,2,3; Gan, Lu1,2,3; Wang, Yali4
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| 刊名 | CELL BIOLOGY INTERNATIONAL
 |
| 出版日期 | 2014-11-01 |
| 卷号 | 38页码:1304-1310 |
| 关键词 | Angiogenesis Bfgf Carbon-ion Irradiation Lung Adenocarcinoma Cells Vegf |
| ISSN号 | 1065-6995 |
| DOI | 10.1002/cbin.10327 |
| 文献子类 | Article |
| 英文摘要 | Radiotherapy has been focused mainly on killing cancer cells, and little attention has been paid to the process supporting tumor growth and metastasis, including the process of angiogenesis. To investigate the effects of carbon-ion irradiation on angiogenesis in lung cancer cells, we examined the expression of vascular endothelial growth factor and basic fibroblast growth factor in the tumor conditioned medium (TCM) of A549 cells exposed to carbon-ion or X-ray irradiation, as well as endothelial cell growth, invasion, and tube formation induced by TCM. No changes in vascular endothelial growth factor secretion were detected in the TCM of A549 cells exposed to carbon-ion irradiation at 2 or 4Gy, whereas 1Gy of irradiation significantly decreased vascular endothelial growth factor and basic fibroblast growth factor levels. Carbon-ion irradiation at 1Gy inhibited endothelial cell invasion and tube formation. The TCM from A549 cells irradiated with X-ray promoted angiogenesis, whereas the TCM of A549 cells exposed to carbon-ion irradiation at 2 or 4Gy had no effect. These findings suggest that carbon-ion irradiation at 1Gy significantly suppressed the process of angiogenesis in vitro by inhibiting endothelial cell invasion and tube formation, which are related to vascular endothelial growth factor and basic fibroblast growth factor production. |
| WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; LYMPHOCYTE-INDUCED ANGIOGENESIS ; PROGNOSTIC-SIGNIFICANCE ; FACTOR EXPRESSION ; BREAST-CARCINOMA ; CANCER ; VEGF ; SURVIVAL ; RADIATION ; APOPTOSIS |
| 资助项目 | Scientific Technology Research Projects of Gansu Province[0702NKDA045] ; Scientific Technology Research Projects of Gansu Province[0806RJYA020] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000342798200009 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.186/handle/113462/49769]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 4.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yuanyuan,Liu, Yang,Zhang, Hong,et al. Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells[J]. CELL BIOLOGY INTERNATIONAL,2014,38:1304-1310. |
| APA | Liu, Yuanyuan.,Liu, Yang.,Zhang, Hong.,Sun, Chao.,Zhao, Qiuyue.,...&Wang, Yali.(2014).Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells.CELL BIOLOGY INTERNATIONAL,38,1304-1310. |
| MLA | Liu, Yuanyuan,et al."Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells".CELL BIOLOGY INTERNATIONAL 38(2014):1304-1310. |
入库方式： OAI收割
来源：近代物理研究所
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