Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures
文献类型：期刊论文
| 作者 | Hu, Wentao1,2; Pei, Hailong1,2; Li, He1,2; Ding, Nan1,2; He, Jinpeng1,2; Wang, Jufang1; Furusawa, Yoshiya3; Hirayama, Ryoichi3; Matsumoto, Yoshitaka3; Liu, Cuihua3 |
| 刊名 | JOURNAL OF RADIATION RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 55页码:10-16 |
| 关键词 | Space Radiation Shielding Secondary Particles Survival Dna Damage |
| ISSN号 | 0449-3060 |
| DOI | 10.1093/jrr/rrt078 |
| 文献子类 | Article |
| 英文摘要 | High atomic number and high-energy (HZE) particles in deep space are of low abundance but substantially contribute to the biological effects of space radiation. Shielding is so far the most effective way to partially protect astronauts from these highly penetrating particles. However, simulated calculations and measurements have predicted that secondary particles resulting from the shielding of cosmic rays produce a significant fraction of the total dose and dose equivalent. In this study, we investigated the biological effects of secondary radiation with two cell types, and with cells exposed in different phases of the cell cycle, by comparing the biological effects of a 200 MeV/u iron beam with a shielded beam in which the energy of the iron ion beam was decreased from 500 MeV/u to 200 MeV/u with PMMA, polyethylene (PE), or aluminum. We found that beam shielding resulted in increased induction of 53BP1 foci and micronuclei in a cell-type-dependent manner compared with the unshielded 200 MeV/u Fe ion beam. These findings provide experimental proof that the biological effects of secondary particles resulting from the interaction between HZE particles and shielding materials should be considered in shielding design. |
| WOS关键词 | SPACE RADIATION PROTECTION ; GALACTIC COSMIC-RAYS ; IONIZING-RADIATION ; HUMAN-CELLS ; DNA-DAMAGE ; HEAVY-IONS ; RISK ; EXPLORATION ; PARTICLES ; LESIONS |
| 资助项目 | National Natural Science Foundations of China[10979062] ; National Natural Science Foundations of China[U1232125] ; National Natural Science Foundations of China[31270895] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000329861800003 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.186/handle/113462/49771]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhou, Guangming |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Inst Modern Phys, Dept Space Radiobiol, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Chiba 263555, Japan 4.Astronaut Ctr China, State Key Lab Space Med Fundamentat & Applicat, Beijing 100094, Peoples R China 5.Keio Univ, Sch Med, Dept Radiol, Tokyo 1608582, Japan |
| 推荐引用方式 GB/T 7714 | Hu, Wentao,Pei, Hailong,Li, He,et al. Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures[J]. JOURNAL OF RADIATION RESEARCH,2014,55:10-16. |
| APA | Hu, Wentao.,Pei, Hailong.,Li, He.,Ding, Nan.,He, Jinpeng.,...&Zhou, Guangming.(2014).Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures.JOURNAL OF RADIATION RESEARCH,55,10-16. |
| MLA | Hu, Wentao,et al."Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures".JOURNAL OF RADIATION RESEARCH 55(2014):10-16. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。