Imaging Intracellular Anticancer Drug Delivery by Self-Assembly Micelles with Aggregation-Induced Emission (AIE Micelles)
文献类型：期刊论文
| 作者 | Zhang, Chunqiu1; Jin, Shubin1; Li, Shengliang1; Xue, Xiangdong1; Liu, Juan1; Huang, Yuran1; Jiang, Yonggang1; Chen, Wei-Qiang2; Zou, Guozhang1; Liang, Xing-Jie1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2014-04-09 |
| 卷号 | 6页码:5212-5220 |
| 关键词 | Tetraphenylethene Self-assembly Micelle Aggregation-induced Emission Imaging Drug Delivery |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/am5005267 |
| 文献子类 | Article |
| 英文摘要 | Nanoformulations show many therapeutic advantages over conventional formulations. We seek to develop traceable nanoformulations in order to closely monitor delivery. Herein, we developed a new drug delivery system (DDS) using tetraphenylethene (TPE) to fabricate a self-assembly micelle with aggregation-induced emission (AIE micelle). AIE makes the nanocarriers visible for high-quality imaging, and the switching on and off of the ME is intrinsically controlled by the assembly and disassembly of the micelles. This DDS was tested for doxorubicin (DOX) delivery and intracellular imaging. For the DOX-loaded micelles (TPED), the DOX content reached as much as 15.3% by weight, and the anticancer efficiency was higher than for free DOX. Meanwhile, high-quality imaging was obtained to trace the intracellular delivery of the TPED. |
| WOS关键词 | IN-VIVO ; POLYMERIC MICELLES ; CANCER-THERAPY ; PHOTODYNAMIC THERAPY ; NANOPARTICLES ; DOXORUBICIN ; DENDRIMERS ; ENCAPSULATION ; VEHICLES ; RELEASE |
| 资助项目 | Chinese Academy of Sciences (CAS) "Hundred Talents Program"[07165111ZX] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000334572800077 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.186/handle/113462/49919]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zou, Guozhang |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Chunqiu,Jin, Shubin,Li, Shengliang,et al. Imaging Intracellular Anticancer Drug Delivery by Self-Assembly Micelles with Aggregation-Induced Emission (AIE Micelles)[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6:5212-5220. |
| APA | Zhang, Chunqiu.,Jin, Shubin.,Li, Shengliang.,Xue, Xiangdong.,Liu, Juan.,...&Liang, Xing-Jie.(2014).Imaging Intracellular Anticancer Drug Delivery by Self-Assembly Micelles with Aggregation-Induced Emission (AIE Micelles).ACS APPLIED MATERIALS & INTERFACES,6,5212-5220. |
| MLA | Zhang, Chunqiu,et al."Imaging Intracellular Anticancer Drug Delivery by Self-Assembly Micelles with Aggregation-Induced Emission (AIE Micelles)".ACS APPLIED MATERIALS & INTERFACES 6(2014):5212-5220. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。