GANRA-5 protects mice from X-ray irradiation-induced dysfunction of the immune system
文献类型：期刊论文
| 作者 | Liu, T.1; Pei, H.1,2; Xu, D.1; Zhang, Y.1; Wan, J.1; Wu, X.1,2; Zhang, X.1,2; Sun, F.1,2; He, J.1,2; Li, P.1,2 |
| 刊名 | FREE RADICAL RESEARCH
 |
| 出版日期 | 2014-08-01 |
| 卷号 | 48页码:875-882 |
| ISSN号 | 1071-5762 |
| 关键词 | Ganra-5 X-rays Immunosuppression Radioprotection |
| DOI | 10.3109/10715762.2014.919389 |
| 文献子类 | Article |
| 英文摘要 | Ionizing radiation produces reactive oxygen species (ROS), which cause damage to cells. We have synthesized a class of ROS scavengers and found that one of them, named GANRA-5, exhibits high radio-protective effects against both heavy ion irradiation and X-rays, while at the same time displaying low levels of toxicity. Pre-administration with an effective dose of GANRA-5 reduces radiation-induced damage to tissues and increases the survival rate of exposed mice. In this study, we evaluated the changes to the immune system via X-ray irradiation, and investigated how pre-administration of GANRA-5 exhibited preventative characteristics. Compared to the irradiated control groups, GANRA-5 treatment significantly reduced the radiation-induced spleen shrinkage and pathological changes. Moreover, pretreatment with GANRA-5 significantly (p < 0.01) enhanced the cellular immune response, which was characterized by higher peritoneal macrophage as well as splenocyte survival, and a higher ratio of CD4(+)/CD8(+) T lymphocytes. In addition, GANRA-5 treatment before whole body irradiation significantly improved the humoral response (p < 0.01) as indicated by the higher antibody titers of IgG, IgA, and IgM. Furthermore, GANRA-5 treatment significantly (p < 0.01) countered radiation-induced decreases in the titers of serum IL-2 and IL-4 when compared to irradiated but untreated control groups. In summary, these findings indicate that GANRA-5 provides effective protection to the immune system against X-ray-induced immunosuppression. |
| WOS关键词 | BODY GAMMA-IRRADIATION ; T-CELLS ; INDUCED IMMUNOSUPPRESSION ; RADIATION-DAMAGE ; HELPER ACTIVITY ; RADIOPROTECTION ; CYTOKINES ; SUBSETS ; INTERLEUKIN-4 ; LYMPHOCYTES |
| 资助项目 | National Natural Science Foundations of China[10979062] ; National Natural Science Foundations of China[U1232125] ; National Natural Science Foundations of China[31270895] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | INFORMA HEALTHCARE |
| WOS记录号 | WOS:000339562600004 |
| 源URL | [http://119.78.100.186/handle/113462/49975]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhou, G. |
| 作者单位 | 1.Chinese Acad Sci, Dept Space Radiobiol, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, T.,Pei, H.,Xu, D.,et al. GANRA-5 protects mice from X-ray irradiation-induced dysfunction of the immune system[J]. FREE RADICAL RESEARCH,2014,48:875-882. |
| APA | Liu, T..,Pei, H..,Xu, D..,Zhang, Y..,Wan, J..,...&Zhou, G..(2014).GANRA-5 protects mice from X-ray irradiation-induced dysfunction of the immune system.FREE RADICAL RESEARCH,48,875-882. |
| MLA | Liu, T.,et al."GANRA-5 protects mice from X-ray irradiation-induced dysfunction of the immune system".FREE RADICAL RESEARCH 48(2014):875-882. |
入库方式： OAI收割
来源：近代物理研究所
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