A COMPARISON OF THE BRAIN UPTAKE OF N-(CYCLOPROPYL[C-11]METHYL) NORBUPRENORPHINE ([C-11]BUPRENORPHINE) AND N-(CYCLOPROPYL[C-11]METHYL NORDIPRENORPHINE ([C-11]DIPRENORPHINE) IN BABOON USING PET
文献类型：期刊论文
| 作者 | SHIUE, CY; BAI, LQ; TENG, RR; ARNETT, CD; DEWEY, SL; WOLF, AP; MCPHERSON, DW; FOWLER, JS; LOGAN, J; HOLLAND, MJ |
| 刊名 | NUCLEAR MEDICINE AND BIOLOGY
 |
| 出版日期 | 1991 |
| 卷号 | 18页码:281-288 |
| ISSN号 | 0883-2897 |
| 英文摘要 | Buprenorphine and diprenorphine were radiolabeled with C-11 and their distributions in the baboon brain were studied using positron emission tomography (PET). Specific binding was demonstrated in the stratum (but not in the cerebellum) by pretreating the baboon with (-)naloxone. The absolute striatal uptakes and time courses were similar for these two radioligands but the ratio of radioactivity in the striatum to cerebellum in the baboon was higher for [C-11]diprenorphine than for [C-11]buprenorphine. Analysis of baboon plasma indicated that both [C-11]diprenorphine and [C-11]buprenorphine are rapidly metabolized. Analysis of radioactivity in mouse brain indicated that these two radioligands are stable to metabolic transformation. At 30 min after injection, 86-90% of extracted radioactivity was due to unchanged C-11-labeled radioligands. These results suggest that both [C-11]diprenorphine and [C-11]buprenorphine may be useful radioligands for studying opioid receptors in humans, although [C-11]diprenorphine may be a better radioligand than [C-11]buprenorphine for this purpose because of its more rapid clearance from the cerebellum. |
| WOS关键词 | C-11 LABELED DIPRENORPHINE ; POSITRON EMISSION TOMOGRAPHY ; RECEPTOR SYSTEM INVIVO ; OPIATE RECEPTORS ; BUPRENORPHINE ; RADIOLIGAND ; RAT ; PHARMACOKINETICS ; DRUGS |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:A1991FF20500003 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.186/handle/113462/56627]  |
| 专题 | 中国科学院近代物理研究所 |
| 作者单位 | 1.BROOKHAVEN NATL LAB,DEPT CHEM,UPTON,NY 11973 2.ACAD SINICA,INST ATOM ENERGY,LANZHOU,PEOPLES R CHINA 3.ACAD SINICA,INST MODERN PHYS,LANZHOU,PEOPLES R CHINA 4.NYU MED CTR,DEPT PSYCHIAT,NEW YORK,NY 10016 |
| 推荐引用方式 GB/T 7714 | SHIUE, CY,BAI, LQ,TENG, RR,et al. A COMPARISON OF THE BRAIN UPTAKE OF N-(CYCLOPROPYL[C-11]METHYL) NORBUPRENORPHINE ([C-11]BUPRENORPHINE) AND N-(CYCLOPROPYL[C-11]METHYL NORDIPRENORPHINE ([C-11]DIPRENORPHINE) IN BABOON USING PET[J]. NUCLEAR MEDICINE AND BIOLOGY,1991,18:281-288. |
| APA | SHIUE, CY.,BAI, LQ.,TENG, RR.,ARNETT, CD.,DEWEY, SL.,...&SIMON, EJ.(1991).A COMPARISON OF THE BRAIN UPTAKE OF N-(CYCLOPROPYL[C-11]METHYL) NORBUPRENORPHINE ([C-11]BUPRENORPHINE) AND N-(CYCLOPROPYL[C-11]METHYL NORDIPRENORPHINE ([C-11]DIPRENORPHINE) IN BABOON USING PET.NUCLEAR MEDICINE AND BIOLOGY,18,281-288. |
| MLA | SHIUE, CY,et al."A COMPARISON OF THE BRAIN UPTAKE OF N-(CYCLOPROPYL[C-11]METHYL) NORBUPRENORPHINE ([C-11]BUPRENORPHINE) AND N-(CYCLOPROPYL[C-11]METHYL NORDIPRENORPHINE ([C-11]DIPRENORPHINE) IN BABOON USING PET".NUCLEAR MEDICINE AND BIOLOGY 18(1991):281-288. |
入库方式： OAI收割
来源：近代物理研究所
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