Detecting the breakup of spiral waves in small-world networks of neurons due to channel block
文献类型：期刊论文
| 作者 | Ma Jun1,2; Huang Long1; Ying HePing3; Pu ZhongSheng1 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2012-06 |
| 卷号 | 57页码:2094-2101 |
| 关键词 | spiral wave factor of synchronization Hodgkin-Huxley neurons small-world networks channel block |
| ISSN号 | 1001-6538 |
| DOI | 10.1007/s11434-012-5114-2 |
| 英文摘要 | The breakup of a spiral wave by blockade of sodium and potassium channels in a small-world network of Hodgkin-Huxley neurons is investigated in detail. The influence of ion channel block in poisoned excitable membrane patches of a certain size is measured, by varying channel noise and channel densities resulting from the change in conductance. For example, tetraethylammonium is known to cause a block (poisoning) of potassium channels, while tetrodotoxin blocks sodium channels. We observed the occurrence of spiral waves, which are ordered waves believed to play an important role in facilitating the propagation of electric signals across quiescent regions of the brain. In this paper, the effect of channel block was measured by the factors x (K) and x (Na), which represent the ratios of unblocked, or active, ion channels, to the overall number of potassium or sodium ion channels, respectively. To quantify these observations, we use a simple but robust synchronization measure, which succinctly captures the transition from spiral waves to other collective states, such as broken segments resulting from the breakup of the spiral wave. The critical thresholds of channel block can be inferred from the abrupt changes occurring in plots of the synchronization measure against different values of x (K) and x (Na). Notably, small synchronization factors can be tightly associated with states where the formation of spiral waves is robust to mild channel block. |
| WOS关键词 | HODGKIN-HUXLEY NEURONS ; SPIKING ACTIVITY ; NOISE ; MEDIA |
| 资助项目 | Natural Science Foundation of Lanzhou University of Technology[Q200706] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000304853100008 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.186/handle/113462/56823]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Ma Jun |
| 作者单位 | 1.Lanzhou Univ Technol, Dept Phys, Lanzhou 730050, Peoples R China 2.Key Lab Gansu Adv Control Ind Proc, Lanzhou 730050, Peoples R China 3.Zhejiang Univ, Zhejiang Inst Modern Phys, Hangzhou 310027, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma Jun,Huang Long,Ying HePing,et al. Detecting the breakup of spiral waves in small-world networks of neurons due to channel block[J]. CHINESE SCIENCE BULLETIN,2012,57:2094-2101. |
| APA | Ma Jun,Huang Long,Ying HePing,&Pu ZhongSheng.(2012).Detecting the breakup of spiral waves in small-world networks of neurons due to channel block.CHINESE SCIENCE BULLETIN,57,2094-2101. |
| MLA | Ma Jun,et al."Detecting the breakup of spiral waves in small-world networks of neurons due to channel block".CHINESE SCIENCE BULLETIN 57(2012):2094-2101. |
入库方式： OAI收割
来源：近代物理研究所
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