X-ray radiation promotes the metastatic potential of tongue squamous cell carcinoma cells via modulation of biomechanical and cytoskeletal properties
文献类型：期刊论文
| 作者 | Zheng, Q.1; Liu, Y.2; Zhou, H. J.3; Du, Y. T.1; Zhang, B. P.4; Zhang, J.1; Miao, G. Y.2; Liu, B.1; Zhang, H.2 |
| 刊名 | HUMAN & EXPERIMENTAL TOXICOLOGY
 |
| 出版日期 | 2015-09 |
| 卷号 | 34页码:894-903 |
| ISSN号 | 0960-3271 |
| 关键词 | X-ray irradiation tongue squamous cell carcinoma metastasis atomic force microscopy biomechanical property actin cytoskeleton |
| DOI | 10.1177/0960327114561664 |
| 英文摘要 | This study investigated the metastatic potential of tongue squamous cell carcinoma (TSCC) cells after X-ray irradiation as well as radiation-induced changes in the biomechanical properties and cytoskeletal structure that are relevant to metastasis. Tca-8113 TSCC cells were X-ray-irradiated at increasing doses (0, 1, 2, or 4 Gy), and 24 h later, migration was evaluated with the wound healing and transwell migration assays, while invasion was assessed with the Matrigel invasion assay. Confocal and atomic force microscopy were used to examine changes in the structure of the actin cytoskeleton and Young's modulus (cell stiffness), respectively. X-ray radiation induced dose-dependent increases in invasive and migratory potentials of cells relative to unirradiated control cells (p < 0.05). The Young's modulus of irradiated cells was decreased by radiation exposure (p < 0.05), which was accompanied by alterations in the integrity and organization of the cytoskeletal network, as evidenced by a decrease in the signal intensity of actin fibers (p < 0.05). X-ray irradiation enhanced migration and invasiveness in Tca-8113 TSCC cells by altering their biomechanical properties and the organization of the actin cytoskeleton. A biomechanics-based analysis can provide an additional platform for assessing tumor response to radiation and optimization of cancer therapies. |
| WOS关键词 | ATOMIC-FORCE MICROSCOPY ; CANCER-CELLS ; INDUCED INCREASE ; LIVING CELLS ; GLIOMA-CELLS ; TUMOR-CELLS ; NECK-CANCER ; IRRADIATION ; MIGRATION ; INVASION |
| 资助项目 | Fundamental Research Funds for the Central Universities[31920130029] ; Fundamental Research Funds for the Central Universities[lzujbky-2014-160] |
| WOS研究方向 | Toxicology |
| 语种 | 英语 |
| 出版者 | SAGE PUBLICATIONS LTD |
| WOS记录号 | WOS:000360090300005 |
| 源URL | [http://119.78.100.186/handle/113462/56856]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Liu, B. |
| 作者单位 | 1.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Dept Radiat Biol and Med, Inst Modern Phys, Lanzhou, Gansu, Peoples R China 3.Northwest Univ Nationalities, Sch Stomatol, Lanzhou, Gansu, Peoples R China 4.Lanzhou Univ, Sch Civil Engn & Mech, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Q.,Liu, Y.,Zhou, H. J.,et al. X-ray radiation promotes the metastatic potential of tongue squamous cell carcinoma cells via modulation of biomechanical and cytoskeletal properties[J]. HUMAN & EXPERIMENTAL TOXICOLOGY,2015,34:894-903. |
| APA | Zheng, Q..,Liu, Y..,Zhou, H. J..,Du, Y. T..,Zhang, B. P..,...&Zhang, H..(2015).X-ray radiation promotes the metastatic potential of tongue squamous cell carcinoma cells via modulation of biomechanical and cytoskeletal properties.HUMAN & EXPERIMENTAL TOXICOLOGY,34,894-903. |
| MLA | Zheng, Q.,et al."X-ray radiation promotes the metastatic potential of tongue squamous cell carcinoma cells via modulation of biomechanical and cytoskeletal properties".HUMAN & EXPERIMENTAL TOXICOLOGY 34(2015):894-903. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。