Radiation-induced robust oscillation and non-Gaussian fluctuation
文献类型：期刊论文
| 作者 | Liu Bo1,2,3; Yan Shi-Wei3,4,5; Geng Yi-Zhao3 |
| 刊名 | CHINESE PHYSICS B
 |
| 出版日期 | 2011-12 |
| 卷号 | 20 |
| 关键词 | nuclear radiation DNA damage non-Gaussian activity robustness |
| ISSN号 | 1674-1056 |
| DOI | 10.1088/1674-1056/20/12/128702 |
| 英文摘要 | There have been many recent studies devoted to the consequences of stochasticity in protein circuitry. Stress conditions, including DNA damage, hypoxia, heat shock, nutrient deprivation, and oncogene activation, can result in the activation and accumulation of p53. Several experimental studies show that oscillations can be induced by DNA damage following nuclear irradiation. To explore the underlying dynamical features and the role of stochasticity, we discuss the oscillatory dynamics in the well-studied regulatory network motif. The fluctuations around the fixed point of a delayed system are Gaussian in the limit of sufficiently weak delayed feedback, and remain Gaussian along a limit cycle when viewed tangential to the trajectory. The experimental results are recapitulated in this study. We illustrate several features of the p53 activities, which are robust when the parameters change. Furthermore, the distribution in protein abundance can be characterized by its non-Gaussian nature. |
| WOS关键词 | STOCHASTIC GENE-EXPRESSION ; P53-MDM2 FEEDBACK LOOP ; DNA-DAMAGE ; SINGLE-CELL ; DYNAMICS ; FEATURES ; SYSTEM ; NOISE ; MODEL ; P53 |
| 资助项目 | Science Foundation of the Ministry of Science and Technology of China[2012CB934001] |
| WOS研究方向 | Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000298493500073 |
| 出版者 | IOP PUBLISHING LTD |
| 源URL | [http://119.78.100.186/handle/113462/56948]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Liu Bo |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China 2.Beijing Normal Univ, Key Lab Beam Technol & Mat Modificat, Minist Educ, Beijing 100875, Peoples R China 3.Beijing Normal Univ, Coll Nucl Sci & Technol, Beijing 100875, Peoples R China 4.Beijing Radiat Ctr, Beijing 100875, Peoples R China 5.Natl Lab Heavy Ion Accelerator Lanzhou, Ctr Theoret Phys, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Bo,Yan Shi-Wei,Geng Yi-Zhao. Radiation-induced robust oscillation and non-Gaussian fluctuation[J]. CHINESE PHYSICS B,2011,20. |
| APA | Liu Bo,Yan Shi-Wei,&Geng Yi-Zhao.(2011).Radiation-induced robust oscillation and non-Gaussian fluctuation.CHINESE PHYSICS B,20. |
| MLA | Liu Bo,et al."Radiation-induced robust oscillation and non-Gaussian fluctuation".CHINESE PHYSICS B 20(2011). |
入库方式： OAI收割
来源：近代物理研究所
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