A dynamical model of DNA-damage derived p53-Mdm2 interaction
文献类型：期刊论文
| 作者 | Zhang Li-Juan; Yan Shi-Wei; Zhuo Yi-Zhong |
| 刊名 | ACTA PHYSICA SINICA
 |
| 出版日期 | 2007-04 |
| 卷号 | 56页码:2442-2447 |
| 关键词 | p53-Mdm2 negative feedback loop sustained and damped oscillations nonlinear dynamical model |
| ISSN号 | 1000-3290 |
| 英文摘要 | The recent experiments on the dynamics of a common biological network motif, p53-Mdm2 feedback loop in population and individual cells shows two different kinds of oscillatory behaviors, namely the damped and sustained oscillations, for the activities of p53 and Mdm2 proteins in response to DNA damage. By exploiting the nonlinear dynamics in the negative feedback loop and through analyzing the dynamical relation between the DNA damage and the activities of p53 and Mdm2 proteins, we propose a nonlinear dynamical model to describe the oscillatory behaviors for the activities of p53 and Mdm2 proteins both in individual and in population of cells in a self-consistent and unified way. |
| WOS关键词 | FEEDBACK LOOP ; P53 ; MDM2 ; EXPRESSION ; CELLS |
| WOS研究方向 | Physics |
| 语种 | 中文 |
| WOS记录号 | WOS:000245844300097 |
| 出版者 | CHINESE PHYSICAL SOC |
| 源URL | [http://119.78.100.186/handle/113462/56962]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Yan Shi-Wei |
| 作者单位 | 1.Beijing Normal Univ, Inst Low Energy Nucl Phys, Beijing 100875, Peoples R China 2.Capital Normal Univ, Dept Phys, Beijing 100037, Peoples R China 3.Natl Lab Heavy Ion Accelerator Lanzhou, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang Li-Juan,Yan Shi-Wei,Zhuo Yi-Zhong. A dynamical model of DNA-damage derived p53-Mdm2 interaction[J]. ACTA PHYSICA SINICA,2007,56:2442-2447. |
| APA | Zhang Li-Juan,Yan Shi-Wei,&Zhuo Yi-Zhong.(2007).A dynamical model of DNA-damage derived p53-Mdm2 interaction.ACTA PHYSICA SINICA,56,2442-2447. |
| MLA | Zhang Li-Juan,et al."A dynamical model of DNA-damage derived p53-Mdm2 interaction".ACTA PHYSICA SINICA 56(2007):2442-2447. |
入库方式： OAI收割
来源：近代物理研究所
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