Oscillatory expression and variability in p53 regulatory network
文献类型：期刊论文
| 作者 | Liu, Bo1; Yan, Shiwei1,2,3; Wang, Qi1; Liu, Shengjun1 |
| 刊名 | PHYSICA D-NONLINEAR PHENOMENA
 |
| 出版日期 | 2011-02 |
| 卷号 | 240页码:259-264 |
| 关键词 | Cancer genetics Master equation Nonlinear feedback p53-Mdm2 system |
| ISSN号 | 0167-2789 |
| DOI | 10.1016/j.physd.2010.09.004 |
| 英文摘要 | The effect of delay, nonlinearity and noise on oscillatory motion is of permanent interest for theoretical and experimental research. Here we explore a negative feedback loop between p53 and Mdm2 with a time delay, which is a key circuit in the response of cells to damage. This circuit shows noisy sustained oscillations in individual human cells following DNA damage, and damped oscillations at the cell population level. We demonstrate the effect of delay on the oscillation, and the correlation in time course. In a multi-species system, the events at different time points which span a time delay are coupled even when the delay is large compared with the other characteristic times of the system. We also clarify that the dynamics at the single-cell level appears to be coherent resonance, and the origin of the damped oscillation at the macroscopic level out of the sustained ones at the single-cell level can be ascribed to the dephasing process which is induced by the interplay between nonlinearity and noise. The findings are consistent with experimental observations and advance our understanding of the dynamics of the p53 network. (C) 2010 Elsevier B.V. All rights reserved. |
| WOS关键词 | P53-MDM2 FEEDBACK LOOP ; BIOLOGICAL NETWORKS ; TIME-DELAY ; SIMULATION ; DYNAMICS ; CELLS ; MODEL |
| 资助项目 | Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Personnel of China[MOP2006138] |
| WOS研究方向 | Mathematics ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000287342900002 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.186/handle/113462/56983]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Yan, Shiwei |
| 作者单位 | 1.Beijing Normal Univ, Coll Nucl Sci & Technol, Beijing 100875, Peoples R China 2.Beijing Radiat Ctr, Beijing 100875, Peoples R China 3.Natl Lab Heavy Ion Accelerator Lanzhou, Ctr Theoret Phys, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Bo,Yan, Shiwei,Wang, Qi,et al. Oscillatory expression and variability in p53 regulatory network[J]. PHYSICA D-NONLINEAR PHENOMENA,2011,240:259-264. |
| APA | Liu, Bo,Yan, Shiwei,Wang, Qi,&Liu, Shengjun.(2011).Oscillatory expression and variability in p53 regulatory network.PHYSICA D-NONLINEAR PHENOMENA,240,259-264. |
| MLA | Liu, Bo,et al."Oscillatory expression and variability in p53 regulatory network".PHYSICA D-NONLINEAR PHENOMENA 240(2011):259-264. |
入库方式： OAI收割
来源：近代物理研究所
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