The hyper-radiosensitivity effect of human hepatoma SMMC-7721 cells exposed to low dose gamma-rays and C-12 ions
文献类型：会议论文
| 作者 | Jin, XD ; Li, Q; Li, WJ; Wang, JF; Guo, CL; Hao, JF
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| 出版日期 | 2006-04 |
| 关键词 | hyper-radiosensitivity increased radio-resistance cell sorter surviving fraction high-LET |
| 卷号 | 245 |
| 期号 | 1 |
| DOI | 10.1016/j.nimb.2005.11.120 |
| 页码 | 310-313 |
| 英文摘要 | Hypersensitive response of mammalian cells in cell killing to X- and gamma-rays has been reported at doses below 1 Gy. The purpose of this study was to examine the low dose sensitivity of human hepatoma SMMC-7721 cells irradiated with Co-60 gamma-rays and 50 MeV/u C-12 ions. Experiments using gamma-rays and charged particle irradiation were performed, particularly in the low dose range from 0 to 2 Gy. The survival effect of SMMC-7721 cells was measured by means of standard clonogenic assay in conjunction with a cell sorter. The result indicates SMMC-7721 cells showed hyper-radiosensitive response at low doses and increased radio-resistance at larger single doses for the carbon ions (LET = 45.2 keV/mu m) and the gamma-rays. However, the HRS/IRR effect caused by high-LET irradiation is different from that by low-LET radiation. This might possibly be due to the difference in the mode of energy deposition by particle beam and low-LET irradiation. (c) 2005 Elsevier B.V. All rights reserved. |
| 会议录 | NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
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| 会议录出版者 | ELSEVIER SCIENCE BV |
| 会议录出版地 | PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| 语种 | 英语 |
| WOS研究方向 | Instruments & Instrumentation ; Nuclear Science & Technology ; Physics |
| WOS记录号 | WOS:000236288500068 |
| 源URL | [http://119.78.100.186/handle/113462/57628]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Jin, XD |
| 作者单位 | Chinese Acad Sci, Grad Sch, Beijing 100040, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, XD,Li, Q,Li, WJ,et al. The hyper-radiosensitivity effect of human hepatoma SMMC-7721 cells exposed to low dose gamma-rays and C-12 ions[C]. 见:. |
入库方式： OAI收割
来源：近代物理研究所
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