Enhanced biological effect induced by a radioactive C-9-ion beam at the depths around its Bragg peak
文献类型：会议论文
| 作者 | Li, Q ; Furusawa, Y; Kanazawa, M; Kanai, T; Kitagawa, A; Aoki, M; Urakabe, E; Sato, S; Wei, Z
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| 出版日期 | 2006-04 |
| 关键词 | radioactive C-9-ion beam enhanced biological effect Bragg peak double irradiation source heavy-ion cancer therapy |
| 卷号 | 245 |
| 期号 | 1 |
| DOI | 10.1016/j.nimb.2005.11.119 |
| 页码 | 302-305 |
| 英文摘要 | To explore the potential of double irradiation source, radioactive C-9-ion beam, in tumor therapy, a comparative study oil the surviving effect of human salivary gland cells at different penetration depths between C-9 and C-12-ion beams has been carried out. The 9C-ion C beam, especially at the distal side of the beam came out more efficient in cell killing at the depths around its Bragg peak than the 12 Bragg peak. Compared to the C-12 beam, an increase in RBE by a factor of up to 2.13 has been observed at the depths distal to the Bragg peak of the 9C beam. The 9C beam showed an enhanced biological effect at the penetration depths around its Bragg peak, corresponding to the stopping region of the incident C-9-ions and where the delayed low-energy particles were emitted. Further analysis revealed that cell lethality by the emitted particles from the stopping C-9-ions is responsible for the excessive biological effect at the penetration depths around the Bragg peak of the C-9 beam. (c) 2005 Elsevier B.V. All rights reserved. |
| 会议录 | NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
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| 会议录出版者 | ELSEVIER SCIENCE BV |
| 会议录出版地 | PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| 语种 | 英语 |
| WOS研究方向 | Instruments & Instrumentation ; Nuclear Science & Technology ; Physics |
| WOS记录号 | WOS:000236288500066 |
| 源URL | [http://119.78.100.186/handle/113462/57824]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Li, Q |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Natl Inst Radiol Sci, Chiba 2638555, Japan |
| 推荐引用方式 GB/T 7714 | Li, Q,Furusawa, Y,Kanazawa, M,et al. Enhanced biological effect induced by a radioactive C-9-ion beam at the depths around its Bragg peak[C]. 见:. |
入库方式： OAI收割
来源：近代物理研究所
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