MMP Inhibitor Ilomastat Improves Survival of Mice Exposed to gamma-Irradiation
文献类型：期刊论文
| 作者 | Li Xiao Man1,2,3,4; Tan Yong3; Huang Chun Qian3; Xu Meng Chuan3; Li Qian3; Pan Dong1,2; Zhao Bao Quan3; Hu Bu Rong1,2 |
| 刊名 | BIOMEDICAL AND ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2018-06 |
| 卷号 | 31页码:467-+ |
| ISSN号 | 0895-3988 |
| DOI | 10.3967/bes2018.062 |
| 英文摘要 | There is still a need for better protection against or mitigation of the effects of ionizing radiation following conventional radiotherapy or accidental exposure. The objective of our current study was to investigate the possible roles of matrix metalloproteinase inhibitor, ilomastat, in the protection of mice from total body radiation (TBI), and the underlying protective mechanisms. Ilomastat treatment increased the survival of mice after TBI. Ilomastat pretreatment promoted recovery of hematological and immunological cells in mice after 6 Gy gamma-ray TBI. Our findings suggest the potential of ilomastat to protect against or mitigate the effects of radiation. |
| WOS关键词 | BONE-MARROW ; CELLS ; MODELS |
| 资助项目 | Military Medical Scientific and Technological Project for the 'Twelfth Five-year Plan'[AWS15J007] |
| WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health |
| 语种 | 英语 |
| WOS记录号 | WOS:000439065700009 |
| 出版者 | CHINESE CENTER DISEASE CONTROL & PREVENTION |
| 源URL | [http://119.78.100.186/handle/113462/59675]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhao Bao Quan; Hu Bu Rong |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Heavy Ion Radiat Biol & Med, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Space Radiobiol Gansu Prov, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 3.Acad Mil Med Sci, Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Xiao Man,Tan Yong,Huang Chun Qian,et al. MMP Inhibitor Ilomastat Improves Survival of Mice Exposed to gamma-Irradiation[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2018,31:467-+. |
| APA | Li Xiao Man.,Tan Yong.,Huang Chun Qian.,Xu Meng Chuan.,Li Qian.,...&Hu Bu Rong.(2018).MMP Inhibitor Ilomastat Improves Survival of Mice Exposed to gamma-Irradiation.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,31,467-+. |
| MLA | Li Xiao Man,et al."MMP Inhibitor Ilomastat Improves Survival of Mice Exposed to gamma-Irradiation".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 31(2018):467-+. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。