Calculation of energy-deposition distributions and microdosimetric estimation of the biological effect of a9C beam
文献类型：期刊论文
| 作者 | Mancusi, Davide1; Sihver, Lembit1,2; Niita, Koji3; Li, Qiang4 ; Sato, Tatsuhiko5; Iwase, Hiroshi6; Iwamoto, Yosuke5; Matsuda, Norihiro5; Sakamoto, Yukio5; Nakashima, Hiroshi5
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| 刊名 | Radiation and Environmental Biophysics
 |
| 出版日期 | 2009 |
| 卷号 | 48页码:135-143 |
| ISSN号 | 0301-634X |
| DOI | 10.1007/s00411-008-0206-8 |
| 英文摘要 | Among the alternative beams being recently considered for external cancer radiotherapy,9C has received some attention because it is expected that its biological effectiveness could be boosted by the β-delayed emission of two α particles and a proton that takes place at the ion-stopping site. Experiments have been performed to characterise this exotic beam physically and models have been developed to estimate quantitatively its biological effect. Here, the particle and heavy-ion transport code system ( PHITS ) is used to calculate energy-deposition and linear energy transfer distributions for a9C beam in water and the results are compared with published data. Although PHITS fails to reproduce some of the features of the distributions, it suggests that the decay of9C contributes negligibly to the energy-deposition distributions, thus contradicting the previous interpretation of the measured data. We have also performed a microdosimetric calculation to estimate the biological effect of the decay, which was found to be negligible; previous microdosimetric Monte-Carlo calculations were found to be incorrect. An analytical argument, of geometrical nature, confirms this conclusion and gives a theoretical upper bound on the additional biological effectiveness of the decay. However, no explanation can be offered at present for the observed difference in the biological effectiveness between9C and12C; the reproducibility of this surprising result will be verified in coming experiments. © 2008 Springer-Verlag. |
| 出版者 | Springer New York LLC |
| 源URL | [http://119.78.100.186/handle/113462/64035]  |
| 专题 | 中国科学院近代物理研究所 |
| 作者单位 | 1.Nuclear Engineering, Applied Physics, Chalmers University of Technology, Göteborg, Sweden 2.Department of Mathematics, Computer Science and Physics, Roanoke College, Salem, VA, United States 3.Research Organisation for Information Science and Technology, Tokai-mura, Japan 4.Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China 5.Japan Atomic Energy Agency, Tokai-mura, Japan 6.Radiation Science, KEK, Oho 1, Tsukuba, Japan |
| 推荐引用方式 GB/T 7714 | Mancusi, Davide,Sihver, Lembit,Niita, Koji,et al. Calculation of energy-deposition distributions and microdosimetric estimation of the biological effect of a9C beam[J]. Radiation and Environmental Biophysics,2009,48:135-143. |
| APA | Mancusi, Davide.,Sihver, Lembit.,Niita, Koji.,Li, Qiang.,Sato, Tatsuhiko.,...&Nakashima, Hiroshi.(2009).Calculation of energy-deposition distributions and microdosimetric estimation of the biological effect of a9C beam.Radiation and Environmental Biophysics,48,135-143. |
| MLA | Mancusi, Davide,et al."Calculation of energy-deposition distributions and microdosimetric estimation of the biological effect of a9C beam".Radiation and Environmental Biophysics 48(2009):135-143. |
入库方式： OAI收割
来源：近代物理研究所
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