Effect of 80.55 MeV/u 12C6+ ions on radiosensitivity and cell cycle of human hepatoma cell lines
文献类型：期刊论文
| 作者 | Wei, Wei1,3 ; Li, Wenjian1; Guo, Chuanling1,3; Jing, Xigang1,3; Jin, Xiaodong1; Su, Xu2
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| 刊名 | Plasma Science and Technology
 |
| 出版日期 | 2008 |
| 卷号 | 10页码:245-249 |
| ISSN号 | 1009-0630 |
| DOI | 10.1088/1009-0630/10/2/22 |
| 英文摘要 | In this paper, the relationship between radiosensitivity, cell cycle alteration and the change of apoptosis in different human hepatoma cell lines irradiated by heavy ions were studied with the aim of building up the base data for clinical therapy. Exponentially growing hepatoma cell lines were irradiated by 80.55 MeV/u12C6+ ions at a dose of 0 Gy, 0.5 Gy, 1 Gy, 2 Gy, 4 Gy and 8 Gy. The radiosensitivity was assessed by means of the colony-forming assay. The DNA content, the percentage of each cell-cycle phase and the apoptosis rate were obtained with flow cytometry methods. After the irradiation, the SF2 (survival fraction at 2 gray) of SMMC-7721 cells were evidently lower than that of HepG2 cells. The S phase arrest, G2/M phase arrest delay and the apoptosis in the two hepatoma cell lines varied with the increase of the dose and repair time. The heavy ions could obviously kill the human hepatoma cell lines. Compared to HepG2 cells, SMMC-7721 cells were more radiosensitive to 12C6+ ions. |
| 出版者 | Institute of Physics Publishing, Temple Back, Bristol, BS1 6BE, United Kingdom |
| 源URL | [http://119.78.100.186/handle/113462/64040]  |
| 专题 | 中国科学院近代物理研究所 |
| 作者单位 | 1.Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2.National Institute for Radiological Protection, China CDC, Beijing 100088, China 3.Graduate School, Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Wei, Wei,Li, Wenjian,Guo, Chuanling,et al. Effect of 80.55 MeV/u 12C6+ ions on radiosensitivity and cell cycle of human hepatoma cell lines[J]. Plasma Science and Technology,2008,10:245-249. |
| APA | Wei, Wei,Li, Wenjian,Guo, Chuanling,Jing, Xigang,Jin, Xiaodong,&Su, Xu.(2008).Effect of 80.55 MeV/u 12C6+ ions on radiosensitivity and cell cycle of human hepatoma cell lines.Plasma Science and Technology,10,245-249. |
| MLA | Wei, Wei,et al."Effect of 80.55 MeV/u 12C6+ ions on radiosensitivity and cell cycle of human hepatoma cell lines".Plasma Science and Technology 10(2008):245-249. |
入库方式： OAI收割
来源：近代物理研究所
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