Radiosensitivity and cell cycle of HepG2 hepatoma cell line irradiated by ionizing radiation with different linear energy transfer
文献类型：期刊论文
| 作者 | Wei, Wei ; Li, Wenjian; Xia, Jingguang; Jin, Xiaodong; Guo, Chuanling; Su, Xu
|
| 刊名 | He Jishu/Nuclear Techniques
 |
| 出版日期 | 2006 |
| 卷号 | 29页码:679-684 |
| ISSN号 | 0253-3219 |
| 英文摘要 | In this paper, the effect of the ionizing radiation with different linear energy transfer on radiosensitivity, cell cycle alteration and the change of apoptosis in HepG2 hepatoma cell lines are studied to build up the base data for clinical therapy. Exponentially growing HepG2 cell lines are irradiated by 12C6+ ions and X-ray at the doses of 0, 0.5, 1, 2, 4 and 8 Gy, respectively. The radiosensitivity is assessed by means of the colony-forming assay. The DNA content, percentage of each cell-cycle phase and the apoptosis rate are obtained with the flow cytometry methods. The results indicate that compared with X-ray, the survival fraction of HepG2 hepatoma cells irradiated by 12C6+ ions is evidently lower, the S phase arrest, G2/M phase arrest delay and the apoptosis in HepG2 cells irradiated by 12C6+ ions are more prominent with the increase of dose and repaired time, thus suggesting that 12C6+ ions can more effectively kill the HepG2 cells and induce apoptosis in the cells than X-ray. |
| 出版者 | Science Press, Beijing, China |
| 源URL | [http://119.78.100.186/handle/113462/64149]  |
| 专题 | 中国科学院近代物理研究所 |
| 作者单位 | 1.Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2.National Institute for Radiological Protection, China CDC, Beijing 100088, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China |
| 推荐引用方式 GB/T 7714 | Wei, Wei,Li, Wenjian,Xia, Jingguang,et al. Radiosensitivity and cell cycle of HepG2 hepatoma cell line irradiated by ionizing radiation with different linear energy transfer[J]. He Jishu/Nuclear Techniques,2006,29:679-684. |
| APA | Wei, Wei,Li, Wenjian,Xia, Jingguang,Jin, Xiaodong,Guo, Chuanling,&Su, Xu.(2006).Radiosensitivity and cell cycle of HepG2 hepatoma cell line irradiated by ionizing radiation with different linear energy transfer.He Jishu/Nuclear Techniques,29,679-684. |
| MLA | Wei, Wei,et al."Radiosensitivity and cell cycle of HepG2 hepatoma cell line irradiated by ionizing radiation with different linear energy transfer".He Jishu/Nuclear Techniques 29(2006):679-684. |
入库方式： OAI收割
来源：近代物理研究所
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