Icariin prevents bone loss by inhibiting bone resorption and stabilizing bone biological apatite in a hindlimb suspension rodent model
文献类型：期刊论文
| 作者 | He, Jin-peng1,2 ; Feng, Xiu1,2,3; Wang, Ju-fang1,2; Shi, Wen-gui1,2,4; Li, He1,2; Danilchenko, Sergei5; Kalinkevich, Aleksei5; Zhovner, Mykhailo5
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2018-11 |
| 卷号 | 39页码:1760-1767 |
| 关键词 | icariin simulated microgravity bone loss hindlimb suspension apatite bone resorption |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-018-0040-8 |
| 英文摘要 | Bone loss induced by microgravity is a substantial barrier to humans in long-term spaceflight. Recent studies have revealed that icariin (ICA) can attenuate osteoporosis in postmenopausal women and ovariectomized rats. However, whether ICA can protect against microgravity-induced bone loss remains unknown. In this study, the effects of ICA on a hindlimb suspension rodent model were investigated. Two-month-old female Wistar rats were hindlimb suspended and treated with ICA (25 mg.kg(-1).d(-1), i.g.) or a vehicle for 4 weeks (n = 6). The bone mass density of the hindlimbs was analyzed using dual-energy X-ray absorptiometry and micro-CT. mRNA expression of osteogenic genes in the tibia and the content of bone metabolism markers in serum were measured using qRT-PCR and ELISA, respectively. The bone mineral phase was analyzed using X-ray diffraction and atomic spectrometry. The results showed that ICA treatment significantly rescued the hindlimb suspension-induced reduction in bone mineral density, trabecular number and thickness, as well as the increases in trabecular separation and the structure model index. In addition, ICA treatment recovered the decreased bone-related gene expression, including alkaline phosphatase (ALP), bone glaprotein (BGP), and osteoprotegerin/receptor activator of the NF-kappa B ligand ratio (OPG/RANKL), in the tibia and the decreased bone resorption marker TRACP-5b levels in serum caused by simulated microgravity. Notably, ICA treatment restored the instability of bone biological apatite and the metabolic disorder of bone mineral elicited by simulated microgravity. These results demonstrate that ICA treatment plays osteoprotective roles in bone loss induced by simulated microgravity by inhibiting bone resorption and stabilizing bone biological apatite. |
| WOS关键词 | X-RAY-DIFFRACTION ; NANOCRYSTALLINE APATITES ; POSTMENOPAUSAL WOMEN ; CONTROLLED TRIAL ; IN-VITRO ; CALCIUM ; OSTEOPOROSIS ; DIFFERENTIATION ; BIOMATERIALS ; SPACEFLIGHT |
| 资助项目 | Science and Technology Research Project of Gansu Province[145RTSA012] ; Science and Technology Research Project of Gansu Province[17JR5RA307] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000448392900009 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.186/handle/113462/64408]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Wang, Ju-fang |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, CAS Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Natl Acad Sci Ukraine, Inst Appl Phys, UA-40000 Sumy, Ukraine |
| 推荐引用方式 GB/T 7714 | He, Jin-peng,Feng, Xiu,Wang, Ju-fang,et al. Icariin prevents bone loss by inhibiting bone resorption and stabilizing bone biological apatite in a hindlimb suspension rodent model[J]. ACTA PHARMACOLOGICA SINICA,2018,39:1760-1767. |
| APA | He, Jin-peng.,Feng, Xiu.,Wang, Ju-fang.,Shi, Wen-gui.,Li, He.,...&Zhovner, Mykhailo.(2018).Icariin prevents bone loss by inhibiting bone resorption and stabilizing bone biological apatite in a hindlimb suspension rodent model.ACTA PHARMACOLOGICA SINICA,39,1760-1767. |
| MLA | He, Jin-peng,et al."Icariin prevents bone loss by inhibiting bone resorption and stabilizing bone biological apatite in a hindlimb suspension rodent model".ACTA PHARMACOLOGICA SINICA 39(2018):1760-1767. |
入库方式： OAI收割
来源：近代物理研究所
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