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Exogenous melatonin modulates carbon ion radiation-induced immune dysfunction in mice

文献类型：期刊论文

作者Mao, Aihong1,2; Guo, Hongyun1; Liu, Yang2; Wang, Fang2; Tang, Jinzhou1,3; Liao, Shiqi1; Zhang, Yongdong1; Sun, Chao2; Xia, Xiaojun1,4; Zhang, Hong2
刊名TOXICOLOGY
出版日期2019-04
卷号417页码:35-41
关键词Melatonin Carbon ion radiation Immune dysfunction Radioprotection
ISSN号0300-483X
DOI10.1016/j.tox.2019.01.019
英文摘要In spite of carbon ion radiotherapy is a talented modality for malignant tumor patients, the radiation damage of normal tissues adjacent to tumor and the dysfunction of immune system limits therapeutic gain. Protecting immune system against carbon ion radiation-caused damage has the possibility to improve cancer treatment, but it is uncertain whether conventional radioprotective agents play a role in carbon ion radiation. To certify carbon ion caused immune dysfunction and assess the radioprotective effect of melatonin on immune system, animal experiments were performed in radiosensitive BALB/C mice. Here, we observed the bodyweight loss, death and apoptosis, abnormal T-cell distributions in immune system in carbon ion radiated mice. Pretreatment with melatonin could increase the index of thymus and spleen, reduce cell apoptosis in thymus and spleen, and attenuate the carbon ion radiation-caused imbalance of T lymphocytes and disorder of cytokines. These results suggest that melatonin can act as an effective protector against carbon ion radiation-caused immune dysfunction. Furthermore, we also found melatonin restored the activity of the antioxidant enzymes and reduced the level of lipid peroxidation in serum. These data have provided baseline information both for radiation workers and cancer patients to use melatonin as a radioprotector during the carbon ion radiation treatment.
WOS关键词IN-VITRO ; DNA-DAMAGE ; SYSTEM ; IRRADIATION ; CELLS
资助项目Cancer Research Youth Science Foundation of Chinese Anti-cancer Association[CAYC18A06]
WOS研究方向Pharmacology & Pharmacy ; Toxicology
语种英语
WOS记录号WOS:000463312500004
出版者ELSEVIER IRELAND LTD
源URL[http://119.78.100.186/handle/113462/69071]  
专题中国科学院近代物理研究所
作者单位1.Gansu Prov Acad Inst Med Res, Lanzhou 730050, Gansu, Peoples R China
2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China
3.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China
4.Gansu Prov Canc Hosp, Lanzhou 730050, Gansu, Peoples R China
推荐引用方式
GB/T 7714		 Mao, Aihong,Guo, Hongyun,Liu, Yang,et al. Exogenous melatonin modulates carbon ion radiation-induced immune dysfunction in mice[J]. TOXICOLOGY,2019,417:35-41.
APA Mao, Aihong.,Guo, Hongyun.,Liu, Yang.,Wang, Fang.,Tang, Jinzhou.,...&Zhang, Hong.(2019).Exogenous melatonin modulates carbon ion radiation-induced immune dysfunction in mice.TOXICOLOGY,417,35-41.
MLA Mao, Aihong,et al."Exogenous melatonin modulates carbon ion radiation-induced immune dysfunction in mice".TOXICOLOGY 417(2019):35-41.

入库方式： OAI收割

来源：近代物理研究所

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