Co-SLD suppressed the growth of oral squamous cell carcinoma via disrupting mitochondrial function
文献类型：期刊论文
| 作者 | Li, Sirui1; Li, Guo1; Zhang, Taofeng3; Li, Jili4; Zhao, Quanyi4; Zhang, Baoping1; Wang, Rui1; Zhou, Rong2; Si, Jing2 ; Gan, Lu2
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| 刊名 | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
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| 出版日期 | 2019 |
| 卷号 | 47页码:1746-1757 |
| 关键词 | Co-SLD oral squamous cell carcinoma antitumor activity zebrafish embryonic toxicity mitochondrial dysfunction |
| ISSN号 | 2169-1401 |
| DOI | 10.1080/21691401.2019.1608218 |
| 英文摘要 | To evaluate the safety and efficacy of novel cobalt complex with sulindac (Co-SLD), the zebrafish and oral squamous cell carcinoma CAL27 were investigated in the present study. The developmental toxicity of Co-SLD ranging from 5 to 20M was determined by exposure to 3-144-h post-fertilization (hpf) zebrafish. Our data showed that Co-SLD did not cause to the appreciable toxicity at low concentration (5 and 10M). A remarkable toxicity was observed at high concentration (20M), including increased mortality and malformation, delayed hatchability, reduced heart rate as well as suppressed behaviour. With regard to the antitumor activity of Co-SLD, inhibited cell growth and migration capability were outstandingly observed in oral squamous cell carcinoma treated with 10 and 20M Co-SLD, which could be mainly attributed to the Co-SLD-elicited mitochondrial damage as marked by the depression of mitochondrial membrane potential, ROS accumulation and ATP depletion. Furthermore, administration of 10M Co-SLD was an optimal concentration not only to avoid the normal tissue toxicity, but also to enhance the killing of cancer cells via disrupting mitochondrial dysfunction. Taken together the above results demonstrated the desirable response of oral squamous cell carcinoma to Co-SLD. |
| WOS关键词 | ZEBRAFISH DANIO-RERIO ; CURRENT TREATMENT OPTIONS ; CARBON-MONOXIDE ; DRUG-RESISTANCE ; PROGNOSTIC-SIGNIFICANCE ; DEVELOPMENTAL TOXICITY ; METASTATIC HEAD ; COMPLEXES ; APOPTOSIS ; CANCER |
| 资助项目 | Scientific Technology Research Projects of Gansu Province[18JR3RA377] ; Scientific Technology Research Projects of Gansu Province[17JR5RA315] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000467126600001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.186/handle/113462/69088]  |
| 专题 | 中国科学院近代物理研究所 |
| 作者单位 | 1.Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730070, Gansu, Peoples R China 3.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou, Gansu, Peoples R China 4.Lanzhou Univ, Sch Pharm, Lanzhou, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Sirui,Li, Guo,Zhang, Taofeng,et al. Co-SLD suppressed the growth of oral squamous cell carcinoma via disrupting mitochondrial function[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2019,47:1746-1757. |
| APA | Li, Sirui.,Li, Guo.,Zhang, Taofeng.,Li, Jili.,Zhao, Quanyi.,...&Liu, Bin.(2019).Co-SLD suppressed the growth of oral squamous cell carcinoma via disrupting mitochondrial function.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,47,1746-1757. |
| MLA | Li, Sirui,et al."Co-SLD suppressed the growth of oral squamous cell carcinoma via disrupting mitochondrial function".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 47(2019):1746-1757. |
入库方式： OAI收割
来源：近代物理研究所
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