Unusual Hypochlorous Acid (HClO) Recognition Mechanism Based on Chlorine-Oxygen Bond (Cl-O) Formation
文献类型：期刊论文
| 作者 | Ma, Jianlong1,2,3; Yan, Chaoxian4; Li, Yijing1,2; Duo, Huixiao1,2,3; Li, Qiang5 ; Lu, Xiaofeng1,2; Guo, Yong1,2
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| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2019-05-23 |
| 卷号 | 25页码:7168-7176 |
| 关键词 | chlorine-oxygen bond fluorescence probes hypochlorous acid near-infrared fluorescence bioimaging |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201806264 |
| 英文摘要 | One of the most important endogenous reactive oxygen species, hypochlorous acid (HClO), is involved in numerous pathological and physiological processes. Herein, a near-infrared fluorescence probe (CyHR) was designed and synthesized for ultrafast (within 0.2 s), sensitive (limit of detection=39.44 nm), and selective response to HClO. The reaction mechanism was systematically analyzed by MS, H-1 NMR spectroscopy, HPLC-MS techniques, and theoretical calculations. The results indicated that HClO can be recognized by CyHR, which is based on chlorine-oxygen (Cl-O) bond formation. To the best of our knowledge, this study is the first to find Cl-O bonds among organic aromatic compounds, given that Cl-O bonds are common among inorganics. Through biological experiments, CyHR was successfully applied to image exogenous and endogenous HClO in macrophage cells (RAW 264.7). Thus, CyHR is a promising tool for HClO-related physiological and pathological studies and may provide a means for designing HClO-specific fluorescence probes. |
| WOS关键词 | 2-PHOTON FLUORESCENT-PROBE ; LIVING CELLS ; QUANTITATIVE APPLICATION ; DENSITY FUNCTIONALS ; SELECTIVE DETECTION ; LIVE CELLS ; MYELOPEROXIDASE ; LYSOSOME ; HOCL ; THERMOCHEMISTRY |
| 资助项目 | National Natural Science Foundation of China[21575149] ; National Natural Science Foundation of China[21505146] ; National Natural Science Foundation of China[21575148] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000469028800015 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/87677]  |
| 专题 | 中国科学院近代物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 5.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Jianlong,Yan, Chaoxian,Li, Yijing,et al. Unusual Hypochlorous Acid (HClO) Recognition Mechanism Based on Chlorine-Oxygen Bond (Cl-O) Formation[J]. CHEMISTRY-A EUROPEAN JOURNAL,2019,25:7168-7176. |
| APA | Ma, Jianlong.,Yan, Chaoxian.,Li, Yijing.,Duo, Huixiao.,Li, Qiang.,...&Guo, Yong.(2019).Unusual Hypochlorous Acid (HClO) Recognition Mechanism Based on Chlorine-Oxygen Bond (Cl-O) Formation.CHEMISTRY-A EUROPEAN JOURNAL,25,7168-7176. |
| MLA | Ma, Jianlong,et al."Unusual Hypochlorous Acid (HClO) Recognition Mechanism Based on Chlorine-Oxygen Bond (Cl-O) Formation".CHEMISTRY-A EUROPEAN JOURNAL 25(2019):7168-7176. |
入库方式： OAI收割
来源：近代物理研究所
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