中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 近代物理研究所
  3. 中国科学院近代物理研究所
Function, clinical application, and strategies of Pre-mRNA splicing in cancer

文献类型：期刊论文

作者Di, Cuixia1,2,3; Syafrizayanti4,5; Zhang, Qianjing1,2,3; Chen, Yuhong1,2,3; Wang, Yupei1,2,3; Zhang, Xuetian1,2,3; Liu, Yang1,2; Sun, Chao1,2; Zhang, Hong1,2; Hoheisel, Jorg D.4
刊名CELL DEATH AND DIFFERENTIATION
出版日期2019-07-01
卷号26页码:1181-1194
ISSN号1350-9047
DOI10.1038/s41418-018-0231-3
英文摘要Pre-mRNA splicing is a fundamental process that plays a considerable role in generating protein diversity. Pre-mRNA splicing is also the key to the pathology of numerous diseases, especially cancers. In this review, we discuss how aberrant splicing isoforms precisely regulate three basic functional aspects in cancer: proliferation, metastasis and apoptosis. Importantly, clinical function of aberrant splicing isoforms is also discussed, in particular concerning drug resistance and radiosensitivity. Furthermore, this review discusses emerging strategies how to modulate pathologic aberrant splicing isoforms, which are attractive, novel therapeutic agents in cancer. Last we outline current and future directions of isoforms diagnostic methodologies reported so far in cancer. Thus, it is highlighting significance of aberrant splicing isoforms as markers for cancer and as targets for cancer therapy.
WOS关键词IN-VITRO ; BCL-X ; ANTISENSE OLIGONUCLEOTIDES ; IONIZING-RADIATION ; CELL-DEATH ; EXPRESSION ; RESISTANCE ; THERAPY ; APOPTOSIS ; ISOFORMS
资助项目national Key R&D project of the Chinese Ministry of Science and Technology[2016YFC0904600] ; Key Program of the National Natural Science Foundation of China[U1432248] ; Key Program of the National Natural Science Foundation of China[U1632270] ; National Natural Science Foundation of China[11675234] ; National Natural Science Foundation of China[11575262] ; Affinomics consortium - European Union[Health-F4-2010-241481] ; Natural Science Foundation of Gansu[17JR5RA310]
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
WOS记录号WOS:000470970300001
出版者NATURE PUBLISHING GROUP
资助机构national Key R&D project of the Chinese Ministry of Science and Technology ; Key Program of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; Affinomics consortium - European Union ; Natural Science Foundation of Gansu
源URL[http://119.78.100.186/handle/113462/87712]  
专题中国科学院近代物理研究所
通讯作者Zhang, Hong; Hoheisel, Jorg D.
作者单位1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Gansu, Peoples R China
2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China
3.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
4.German Canc Res Ctr, Div Funct Genome Anal, Neuenheimer Feld 580, D-69120 Heidelberg, Germany
5.Andalas Univ, Fac Math & Nat Sci, Dept Chem, Kampus Limau Manis, Padang, Indonesia
推荐引用方式
GB/T 7714		 Di, Cuixia,Syafrizayanti,Zhang, Qianjing,et al. Function, clinical application, and strategies of Pre-mRNA splicing in cancer[J]. CELL DEATH AND DIFFERENTIATION,2019,26:1181-1194.
APA Di, Cuixia.,Syafrizayanti.,Zhang, Qianjing.,Chen, Yuhong.,Wang, Yupei.,...&Hoheisel, Jorg D..(2019).Function, clinical application, and strategies of Pre-mRNA splicing in cancer.CELL DEATH AND DIFFERENTIATION,26,1181-1194.
MLA Di, Cuixia,et al."Function, clinical application, and strategies of Pre-mRNA splicing in cancer".CELL DEATH AND DIFFERENTIATION 26(2019):1181-1194.

入库方式： OAI收割

来源：近代物理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。