Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity
文献类型：期刊论文
| 作者 | Zhou, Heng3,4,5,6,7; Perez-Lanzon, Maria3,4,5,6; Humeau, Juliette3,4,5,6; Wang, Yan3,4,5,6; Senovilla, Laura3,4,5,6; Sauvat, Allan3,4,5,6; Iribarren, Kristina3,4,5,6; Forveille, Sabrina3,4,5,6; Xie, Wei3,4,5,6; Kepp, Oliver3,4,5,6 |
| 刊名 | ONCOIMMUNOLOGY
 |
| 出版日期 | 2019-11-02 |
| 卷号 | 8期号:11页码:9 |
| ISSN号 | 2162-402X |
| 关键词 | Anticancer immunity immunogenic cell death checkpoint blockade tumor clearance |
| DOI | 10.1080/2162402X.2019.1656502 |
| 通讯作者 | Kroemer, Guido(kroemer@orange.fr) ; Kepp, Oliver(captain.olsen@gmail.com) |
| 英文摘要 | Systemic treatment with the active transcription inhibitor lurbinectedin aims at inducing tumor cell death in hyperproliferative neoplasms. Here we show that cell death induced by lurbinectedin reinstates and enhances systemic anticancer immune responses. Lurbinectedin treatment showed traits of immunogenic cell death, including the exposure of calreticulin, the release of ATP, the exodus of high mobility group box 1 (HMGB1) and type 1 interferon responses in vitro. Lurbinectedin treated cells induced antitumor immunity when injected into immunocompetent animals and treatment of transplanted fibrosarcomas reduced tumor growth in immunocompetent yet not in immunodeficient hosts. Anticancer effects resulting from lurbinectedin treatment were boosted in combination with PD-1 and CTLA-4 double immune checkpoint blockade (ICB), and lurbinectedin combined with double ICB exhibited strong antineoplastic effects. Cured animals exhibited long term immune memory effects that rendered them resistant to rechallenge with syngeneic tumors underlining the potency of combination therapy with lurbinectedin. |
| WOS关键词 | CHEMOTHERAPY ; IMMUNOGENICITY ; PROGNOSIS ; EFFICACY |
| 资助项目 | China Scholarship Council ; Foundation Philanthropia ; Ligue contre le Cancer (equipe labellisee) ; Agence National de la Recherche (ANR) -Projets blancs ; ANR ; Association pour la recherche sur le cancer (ARC) ; Canceropole Ile-deFrance ; Chancelerie des universites de Paris (Legs Poix), Fondation pour la Recherche Medicale (FRM) ; European Research Area Network on Cardiovascular Diseas (ERA-CVD, MINOTAUR) ; Gustave Roussy Odyssea ; European Union ; High-end Foreign Expert Program in China, Institut National du Cancer (INCa)[GDW20171100085] ; High-end Foreign Expert Program in China, Institut National du Cancer (INCa)[GDW20181100051] ; Inserm (HTE) ; Institut Universitaire de France ; LeDucq Foundation ; LabEx Immuno-Oncology ; Seerave Foundation ; SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE) ; SIRIC Cancer Research and Personalized Medicine (CARPEM) ; RHU Torino Lumiere ; Fondation Carrefour |
| WOS研究方向 | Oncology ; Immunology |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS INC |
| WOS记录号 | WOS:000485155100001 |
| 资助机构 | China Scholarship Council ; Foundation Philanthropia ; Ligue contre le Cancer (equipe labellisee) ; Agence National de la Recherche (ANR) -Projets blancs ; ANR ; Association pour la recherche sur le cancer (ARC) ; Canceropole Ile-deFrance ; Chancelerie des universites de Paris (Legs Poix), Fondation pour la Recherche Medicale (FRM) ; European Research Area Network on Cardiovascular Diseas (ERA-CVD, MINOTAUR) ; Gustave Roussy Odyssea ; European Union ; High-end Foreign Expert Program in China, Institut National du Cancer (INCa) ; Inserm (HTE) ; Institut Universitaire de France ; LeDucq Foundation ; LabEx Immuno-Oncology ; Seerave Foundation ; SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE) ; SIRIC Cancer Research and Personalized Medicine (CARPEM) ; RHU Torino Lumiere ; Fondation Carrefour |
| 源URL | [http://119.78.100.186/handle/113462/132786]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Kepp, Oliver; Kroemer, Guido |
| 作者单位 | 1.Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden 2.PharmaMar, Madrid, Spain 3.Univ Paris 06, Paris, France 4.Univ Paris 05, Sorbonne Paris Cite, Paris, France 5.Ctr Rech Cordeliers, Equipe 11 Labellisee Ligue Canc, Paris, France 6.Gustave Roussy Comprehens Canc Inst, Metabol & Cell Biol Platforms, Villejuif, France 7.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Gansu, Peoples R China 8.Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France 9.Chinese Acad Med Sci, Suzhou Inst Syst Med, Suzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Heng,Perez-Lanzon, Maria,Humeau, Juliette,et al. Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity[J]. ONCOIMMUNOLOGY,2019,8(11):9. |
| APA | Zhou, Heng.,Perez-Lanzon, Maria.,Humeau, Juliette.,Wang, Yan.,Senovilla, Laura.,...&Kroemer, Guido.(2019).Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity.ONCOIMMUNOLOGY,8(11),9. |
| MLA | Zhou, Heng,et al."Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity".ONCOIMMUNOLOGY 8.11(2019):9. |
入库方式： OAI收割
来源：近代物理研究所
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