Transforming growth factor beta signaling pathway: A promising therapeutic target for cancer
文献类型：期刊论文
| 作者 | Yang, Hongying5; Zhang, Hong2,3,4,6 ; Zhang, Qianjing2,3,4,6; Zhang, Jinhua2,3,4,6; Xu, Caipeng2,3,4,6; Yan, Jun-fang2,3,4,6; Wang, Fang2,3,4,6; Wang, Jing1; Zhang, Xuetian2,3,4,6; Di, Cuixia2,3,4,6
|
| 刊名 | JOURNAL OF CELLULAR PHYSIOLOGY
 |
| 出版日期 | 2019-07-22 |
| 页码 | 12 |
| 关键词 | clinical application drug inhibitors TGF-beta tumor |
| ISSN号 | 0021-9541 |
| DOI | 10.1002/jcp.29108 |
| 通讯作者 | Di, Cuixia(dicx@impcas.ac.cn) ; Zhang, Hong(zhangh@impcas.ac.cn) |
| 英文摘要 | Transforming growth factor beta (TGF-beta) is part of the transforming growth factor beta superfamily which is involved in many physiological processes and closely related to the carcinogenesis. Here, we discuss the TGF-beta structure, function, and its canonical Smads signaling pathway. Importantly, TGF-beta has been proved that it plays both tumor suppressor as well as an activator role in tumor progression. In an early stage, TGF-beta inhibits cell proliferation and is involved in cell apoptosis. In an advanced tumor, TGF-beta signaling pathway induces tumor invasion and metastasis through promoting angiogenesis, epithelial-mesenchymal transition, and immune escape. Furthermore, we are centered on updated research results into the inhibitors as drugs which have been studied in preclinical or clinical trials in tumor carcinogenesis to prevent the TGF-beta synthesis and block its signaling pathways such as antibodies, antisense molecules, and small-molecule tyrosine kinase inhibitors. Thus, it is highlighting the crucial role of TGF-beta in tumor therapy and may provide opportunities for the new antitumor strategies in patients with cancer. |
| WOS关键词 | I KINASE INHIBITOR ; NONSMALL CELL LUNG ; EPITHELIAL-MESENCHYMAL TRANSITION ; HIGH-GRADE GLIOMA ; RECEPTOR-TYPE-I ; TGF-BETA ; PROSTATE-CANCER ; TGF-BETA-1-INDUCED EMT ; LY2157299 MONOHYDRATE ; MONOCLONAL-ANTIBODY |
| 资助项目 | National Key R&D project of the Chinese Ministry of Science and Technology[2018YFE0205100] ; Key Program of the National Natural Science Foundation of China[U1632270] ; National Natural Science Foundation of China[11675234] ; National Natural Science Foundation of China[11875061] ; Natural Science Foundation of Gansu[17JR5RA310] |
| WOS研究方向 | Cell Biology ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000478454200001 |
| 出版者 | WILEY |
| 资助机构 | National Key R&D project of the Chinese Ministry of Science and Technology ; Key Program of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Gansu |
| 源URL | [http://119.78.100.186/handle/113462/133029]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong; Di, Cuixia |
| 作者单位 | 1.Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing, Peoples R China 4.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 5.Soochow Univ, Med Coll, Suzhou, Peoples R China 6.Chinese Acad Sci, Dept Radiat Med, Inst Modern Phys, Lanzhou, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Hongying,Zhang, Hong,Zhang, Qianjing,et al. Transforming growth factor beta signaling pathway: A promising therapeutic target for cancer[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2019:12. |
| APA | Yang, Hongying.,Zhang, Hong.,Zhang, Qianjing.,Zhang, Jinhua.,Xu, Caipeng.,...&Li, Hongyan.(2019).Transforming growth factor beta signaling pathway: A promising therapeutic target for cancer.JOURNAL OF CELLULAR PHYSIOLOGY,12. |
| MLA | Yang, Hongying,et al."Transforming growth factor beta signaling pathway: A promising therapeutic target for cancer".JOURNAL OF CELLULAR PHYSIOLOGY (2019):12. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。