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Integrating radiosensitive genes improves prediction of radiosensitivity or radioresistance in patients with oesophageal cancer

文献类型：期刊论文

作者Yang, Yan3; Kong, Yarong4; Li, Yi4; Liu, Ruifeng3,4; Wang, Xiaohu3,4; Tian, Jinhui1,2; Bing, Zhitong1,2; Zhang, Qiuning3,4
刊名ONCOLOGY LETTERS
出版日期2019-06-01
卷号17期号:6页码:5377-5388
关键词oesophageal cancer radiosensitive gene signature prognosis clinical outcome prognostic index
ISSN号1792-1074
DOI10.3892/ol.2019.10240
通讯作者Wang, Xiaohu(xhwanggansu@163.com)
英文摘要Oesophageal cancer is a serious disease worldwide. In China, the incidence of esophageal cancer was reported to be similar to 478,000 in 2015. In the same year, the incidence of esophageal cancer in the United States was similar to 16,910. Radiotherapy serves as an important tool in the treatment of oesophageal cancer, and although radiation therapy has progressed over time, the prognosis of the majority of patients with oesophageal cancer remains poor. Additionally, the sensitivity of patients with oesophageal cancer to radiotherapy and chemotherapy is not yet clear. Although there are a number of studies on the radiosensitivity of oesophageal cancer cell lines, the vastly different results from different cell lines make them unreliable to use as a guide in clinical practice. Therefore, a common radiosensitive gene signature may provide more reliable results, and using different combinations of common gene signatures to predict the outcome of patients with oesophageal cancer may generate a unique gene signature in oesophageal cancer. In the present study, the radiosensitive index and prognostic index were calculated to predict clinical outcomes. The prognostic index of a 41-gene signature combination is the largest combination of gene signatures used for classifying oesophageal cancer patients into radiosensitive (RS) and radioresistance (RR) groups, to the best of our knowledge, and this gene signature was more effective in patients classified as having Stage III oesophageal cancer. Furthermore, four genes (carbonyl reductase 1, serine/threonine kinase PAK2, ras-related protein Rab 13 and twinfilin-1) may be sufficient to classify patients into either RS or RR. Subsequent to gene enrichment analysis, the cell communication pathway was significantly different between RS and RR groups in oesophageal cancer. These results may provide useful insights in improving radiotherapy strategies in clinical decisions.
WOS关键词NASOPHARYNGEAL CARCINOMA ; H2AX PHOSPHORYLATION ; MOLECULAR SIGNATURE ; INDEX PREDICTS ; DNA-REPAIR ; CELL-LINES ; RADIATION ; EXPRESSION ; RADIOTHERAPY ; IDENTIFICATION
资助项目Gansu Province Science Foundation[1606RJZA016]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000471330400077
出版者SPANDIDOS PUBL LTD
资助机构Gansu Province Science Foundation
源URL[http://119.78.100.186/handle/113462/133142]  
专题中国科学院近代物理研究所
通讯作者Wang, Xiaohu
作者单位1.Chinese Acad Sci, Inst Modern Phys, Dept Computat Phys, Lanzhou 730000, Gansu, Peoples R China
2.Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou 730050, Gansu, Peoples R China
3.Lanzhou Univ, Clin Med Coll 1, Gansu Prov Canc Hosp, Lanzhou, Gansu, Peoples R China
4.Lanzhou Univ, Clin Med Coll 1, Dept Radiat Oncol, 222 Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yan,Kong, Yarong,Li, Yi,et al. Integrating radiosensitive genes improves prediction of radiosensitivity or radioresistance in patients with oesophageal cancer[J]. ONCOLOGY LETTERS,2019,17(6):5377-5388.
APA Yang, Yan.,Kong, Yarong.,Li, Yi.,Liu, Ruifeng.,Wang, Xiaohu.,...&Zhang, Qiuning.(2019).Integrating radiosensitive genes improves prediction of radiosensitivity or radioresistance in patients with oesophageal cancer.ONCOLOGY LETTERS,17(6),5377-5388.
MLA Yang, Yan,et al."Integrating radiosensitive genes improves prediction of radiosensitivity or radioresistance in patients with oesophageal cancer".ONCOLOGY LETTERS 17.6(2019):5377-5388.

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来源：近代物理研究所

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