The mechanisms for the radioprotective effect of beta-D-glucan on high linear-energy-transfer carbon ion irradiated mice
文献类型：期刊论文
| 作者 | Liu, Fang2,3; Zhang, Miaomiao2 ; Du, Yan2; Wei, Yanting1; Zhou, Libin2; Li, Wenjian2; Wang, Zhuanzi2
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2019-06-15 |
| 卷号 | 131页码:282-292 |
| 关键词 | S. cerevisiae-derived-beta-D-glucan Carbon ion irradiation Murine bone marrow Radioprotective mechanism |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2019.03.073 |
| 通讯作者 | Wang, Zhuanzi(wangzz@impcas.ac.cn) |
| 英文摘要 | S. cerevisiae-derived-beta-D-glucan (S. cerevisiae-BG) is a natural polysaccharide with various biological effects. The present study was to investigate the protective effect of S. cerevisiae-BG on the injury induced by high linear-energy-transfer (LET) carbon ion irradiation and to reveal the protective mechanisms. Female mice were orally administrated with S. cerevisiae-BG before irradiation. 30-day survival of 6 Gy irradiated-mice was monitored. The damage and recovery of hematopoietic system were evaluated after 2 Gy irradiation, cytokines in plasma were detected, transcriptomics of bone marrow mononuclear cells (BMMNCs) were detected and analyzed. The mortality results showed that S. cerevisiae-BG could prolong the survival of mice exposed to 6 Gy. The results of BMMNCs injury analysis showed that S. cerevisiae-BG could reduce the ROS level, mitigate DNA damage and apoptosis. S. cerevisiae-BG increased the plasma radioprotective cytokines level in irradiated mice. Transcriptomics analysis revealed that S. cerevisiae-BG modulated the gene expression in BMMNCs of irradiated mice, 256 genes were significantly up-regulated and 97 genes were significantly down-regulated. Gene function and Gene Ontology analysis indicated the key genes related to hematopoiesis and immunity. Pathway analysis revealed that these up-regulated genes mainly focus on PI3K-Akt pathway and down-regulated genes mainly focus on MAPK pathway. These data contribute to understanding the molecular mechanisms of the radioprotective effect of S. cerevisiae-BG. (C) 2019 Elsevier B.V. All rights reserved. |
| WOS关键词 | HEMATOPOIETIC STEM-CELLS ; SYSTEM ; ENHANCEMENT ; RECOVERY ; CADHERIN ; YEAST ; IL-3 |
| 资助项目 | National Natural Science Foundation of China ; NSFC[11575259] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000468252800032 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | National Natural Science Foundation of China ; NSFC |
| 源URL | [http://119.78.100.186/handle/113462/133490]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Wang, Zhuanzi |
| 作者单位 | 1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Fang,Zhang, Miaomiao,Du, Yan,et al. The mechanisms for the radioprotective effect of beta-D-glucan on high linear-energy-transfer carbon ion irradiated mice[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2019,131:282-292. |
| APA | Liu, Fang.,Zhang, Miaomiao.,Du, Yan.,Wei, Yanting.,Zhou, Libin.,...&Wang, Zhuanzi.(2019).The mechanisms for the radioprotective effect of beta-D-glucan on high linear-energy-transfer carbon ion irradiated mice.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,131,282-292. |
| MLA | Liu, Fang,et al."The mechanisms for the radioprotective effect of beta-D-glucan on high linear-energy-transfer carbon ion irradiated mice".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 131(2019):282-292. |
入库方式： OAI收割
来源：近代物理研究所
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