Astragalus Polysaccharide Eases G1 Phase-Correlative Bystander Effects through Mediation of TGF-beta R/MAPK/ROS Signal Pathway After Carbon Ion Irradiation in BMSCs
文献类型：期刊论文
| 作者 | Wang, Lei3; Zhang, Li-Ying3; Liu, Yong-Qi3; He, Jin-Peng1,2 ; Gong, Hong-Xia3; Zhang, Yi-Ming3; Zhang, Li-Xin3; Yong, Wen-Xing4
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| 刊名 | AMERICAN JOURNAL OF CHINESE MEDICINE
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| 出版日期 | 2019 |
| 卷号 | 47期号:3页码:595-612 |
| 关键词 | BMSCs Bystander Effect Astragalus Polysaccharide MAPK TGF-beta |
| ISSN号 | 0192-415X |
| DOI | 10.1142/S0192415X19500319 |
| 通讯作者 | Liu, Yong-Qi(liuyongqi73@163.com) |
| 英文摘要 | Although Astragalus polysaccharide (APS) has been shown to have various pharmacological effects, there have been no studies concerning the inhibitory effects of APS on the radiation-induced bystander effects (RIBE). The aim of this study was to investigate whether APS could suppress RIBE damage by inhibiting cell growth, micronucleus (MN) formation and 53BP1 foci number increased in bone marrow mesenchymal stem cells (BMSCs), named bystander cells, as well as to explore its mechanism. In this study, APS decreased proliferation and colony rate of bystander cells by inducing cell cycle arrest at G1 phase via extrinsic and intrinsic DNA damage. Regarding mechanism, APS inhibited mitogen-activated protein kinase (MAPK) signal pathway by down-regulating the expression of the key proteins, phosphorylated JNK (p-JNK), phosphorylated ERK (p-ERK) but not phosphorylated P38 (p-P38), and down-regulating their downstream function protein and molecule, cyclooxygenase-2 (COX-2) and reactive oxygen species (ROS). Moreover, in by-stander cells, APS inhibits expression of transforming growth factor beta receptor II (TGF-beta RII), a cell membrane receptor, resulting in lower ROS production and secretion via TGF-beta R-JNK/ERK-COX-2/ROS not P38 signaling. They gave a hint that the decreased RIBE damage induced by APS treatment involved TGF-beta R-JNK/ERK-COX-2/ROS down-regulation. |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; INTERCELLULAR COMMUNICATION ; LUNG-CANCER ; TNF-ALPHA ; GAMMA-H2AX ; STRESS ; RESPONSES ; DAMAGE ; ROLES |
| 资助项目 | National Natural Science Foundation of China[81473457] ; National Natural Science Foundation of China[81660730] ; Collaborative Innovation Project of Chinese and Tibetan Medicine[XBXT2015-1] ; Project of Gansu Provincial Education Department[2015A-095] ; Project of Lanzhou Municipal Science and Technology Bureau[2015-2-48] |
| WOS研究方向 | Integrative & Complementary Medicine ; General & Internal Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000468960700007 |
| 出版者 | WORLD SCIENTIFIC PUBL CO PTE LTD |
| 资助机构 | National Natural Science Foundation of China ; Collaborative Innovation Project of Chinese and Tibetan Medicine ; Project of Gansu Provincial Education Department ; Project of Lanzhou Municipal Science and Technology Bureau |
| 源URL | [http://119.78.100.186/handle/113462/133642]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Liu, Yong-Qi |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 3.Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China 4.Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lei,Zhang, Li-Ying,Liu, Yong-Qi,et al. Astragalus Polysaccharide Eases G1 Phase-Correlative Bystander Effects through Mediation of TGF-beta R/MAPK/ROS Signal Pathway After Carbon Ion Irradiation in BMSCs[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2019,47(3):595-612. |
| APA | Wang, Lei.,Zhang, Li-Ying.,Liu, Yong-Qi.,He, Jin-Peng.,Gong, Hong-Xia.,...&Yong, Wen-Xing.(2019).Astragalus Polysaccharide Eases G1 Phase-Correlative Bystander Effects through Mediation of TGF-beta R/MAPK/ROS Signal Pathway After Carbon Ion Irradiation in BMSCs.AMERICAN JOURNAL OF CHINESE MEDICINE,47(3),595-612. |
| MLA | Wang, Lei,et al."Astragalus Polysaccharide Eases G1 Phase-Correlative Bystander Effects through Mediation of TGF-beta R/MAPK/ROS Signal Pathway After Carbon Ion Irradiation in BMSCs".AMERICAN JOURNAL OF CHINESE MEDICINE 47.3(2019):595-612. |
入库方式： OAI收割
来源：近代物理研究所
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