Chromo-Fluorogenic Detection of Soman and Its Simulant by Thiourea-Based Rhodamine Probe
文献类型：期刊论文
| 作者 | Zheng, Yongchao1,2; Chen, Weiqiang3; Zheng, Meiling4,5; Zheng, He1,2; Zhang, Zhe1; Cui, Yan1,2; Zhong, Jinyi1,2; Zhao, Chonglin1,2; Li, Shengsong1 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 24期号:5页码:12 |
| 关键词 | Nerve agents Soman Rhodamine B Thiosemicarbazide Chromo-fluorogenic probe Detection |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules24050827 |
| 通讯作者 | Zheng, Yongchao(zhengycfh@163.com) ; Zhong, Jinyi(linfzjy@163.com) ; Zhao, Chonglin(zhaochonglin@126.com) |
| 英文摘要 | Here, we introduced a novel thiourea-based rhodamine compound as a chromo-fluorogenic indicator of nerve agent Soman and its simulant diethyl chlorophosphate (DCP). The synthesized probe N-(rhodamine B)-lactam-2-(4-cyanophenyl) thiourea (RB-CT), which has a rhodamine core linked by a cyanophenyl thiosemicarbazide group, enabled a rapidly and highly sensitive response to DCP with clear fluorescence and color changes. The detection limit was as low as 2 x 10(-6) M. The sensing mechanism showed that opening of the spirolactam ring following the phosphorylation of thiosemicarbazides group formed a seven-membered heterocycle adduct, according to MS analysis and TD-DFT calculations. RB-CT exhibited high detecting selectivity for DCP, among other organophosphorus compounds. Moreover, two test kits were employed and successfully used to detect real nerve agent Soman in liquid and gas phase. |
| WOS关键词 | MOLECULAR-ORBITAL METHODS ; NERVE AGENT SIMULANT ; VISUAL DETECTION ; RAPID DETECTION ; SARIN ; DCNP ; FLUORESCENT ; DCP ; NANOPARTICLES ; LIQUID |
| 资助项目 | National Key Research and Development Program of China[2017YFC0108500] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000462662900003 |
| 出版者 | MDPI |
| 资助机构 | National Key Research and Development Program of China |
| 源URL | [http://119.78.100.186/handle/113462/133833]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zheng, Yongchao; Zhong, Jinyi; Zhao, Chonglin |
| 作者单位 | 1.Res Inst Chem Def, Beijing 102205, Peoples R China 2.State Key Lab NBC Protect Civilian, Beijing 102205, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 4.Chinese Acad Sci, Lab Organ NanoPhoton, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 5.Chinese Acad Sci, CAS Key Lab Bioinspired Mat & Interfacial Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Yongchao,Chen, Weiqiang,Zheng, Meiling,et al. Chromo-Fluorogenic Detection of Soman and Its Simulant by Thiourea-Based Rhodamine Probe[J]. MOLECULES,2019,24(5):12. |
| APA | Zheng, Yongchao.,Chen, Weiqiang.,Zheng, Meiling.,Zheng, He.,Zhang, Zhe.,...&Li, Shengsong.(2019).Chromo-Fluorogenic Detection of Soman and Its Simulant by Thiourea-Based Rhodamine Probe.MOLECULES,24(5),12. |
| MLA | Zheng, Yongchao,et al."Chromo-Fluorogenic Detection of Soman and Its Simulant by Thiourea-Based Rhodamine Probe".MOLECULES 24.5(2019):12. |
入库方式： OAI收割
来源：近代物理研究所
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