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Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation

文献类型：期刊论文

作者Liu, Fang1,3; Wang, Zhuanzi1; Li, Wenjian1; Wei, Yanting2
刊名MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
出版日期2019-03-01
卷号839页码:49-58
关键词RNA-seq Transcriptomics
ISSN号1383-5718
DOI10.1016/j.mrgentox.2019.01.014
通讯作者Wang, Zhuanzi(wangzz@impcas.ac.cn)
英文摘要The need to understand the health effects of heavy ion irradiation is motivated by the use of this modality in radiotherapy and by the potential for exposure during space missions. We have studied the effects of carbon-ion total-body irradiation on the hematopoietic system of the mouse and, in particular, the transcriptional response of bone marrow (BM) cells. Carbon-ion irradiation caused BM cell DNA damage, apoptosis, elevated ROS, and myelosuppression. Transcriptomic analysis showed that overall gene expression in irradiated BM cells differed significantly from the controls. Of 253 genes that were modulated, 192 were up-regulated and 61 down-regulated. Gene ontology analysis showed that the modulated genes are involved in DNA damage response signaling, DNA repair, apoptosis, and the immune response. Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that these functions are regulated by the p38 MAPK, TNF, and apoptosis pathways. These findings indicate pathways that may be involved in protection against carbon ion radiation injury.
WOS关键词DNA-DAMAGE ; RADIATION ; EXPOSURE ; GENE ; EXPRESSION ; PROGENITOR ; LEUKEMIA ; REPAIR ; DEATH
资助项目National Natural Science Foundation of China ; NSFC[11575259]
WOS研究方向Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
语种英语
WOS记录号WOS:000459842200007
出版者ELSEVIER SCIENCE BV
资助机构National Natural Science Foundation of China ; NSFC
源URL[http://119.78.100.186/handle/113462/134633]  
专题中国科学院近代物理研究所
通讯作者Wang, Zhuanzi
作者单位1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China
2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Gansu, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Fang,Wang, Zhuanzi,Li, Wenjian,et al. Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS,2019,839:49-58.
APA Liu, Fang,Wang, Zhuanzi,Li, Wenjian,&Wei, Yanting.(2019).Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation.MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS,839,49-58.
MLA Liu, Fang,et al."Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation".MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 839(2019):49-58.

入库方式： OAI收割

来源：近代物理研究所

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