Unraveling the mystery of enhanced cell-killing effect around the Bragg peak region of a double irradiation source C-9-ion beam
文献类型：期刊论文
| 作者 | Kanazawa, M; Li, Q ; Furusawa, Y; Kitagawa, A
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| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2005-11-01 |
| 卷号 | 50期号:22页码:2546-2551 |
| 关键词 | double irradiation source enhanced cell-killing effect ion-stopping distribution mean lethal event clustered damage |
| ISSN号 | 1001-6538 |
| DOI | 10.1360/982005-419 |
| 英文摘要 | An enhanced cell-killing effect at the penetration depths around the Bragg peak of a P-delayed particle decay C-9-ion beam has been observed in our preceding radiobiological experiments in comparison with a therapeutic 12 C beam under the same conditions, and RBE values of the C-9 beam were revealed to be higher than those of the comparative 12 C beam by a factor of up to 2. This study is aimed at investigating the biophysical mechanisms underlying the important experimental phenomenon. First of all, a model for calculating the stopping probability density of the experimentally applied C-9 beam is worked out, where all determinants such as the initial momentum spread of the C-9 beam, the fluence attenuation with penetration depth due to the projectile-target nuclear reaction and the energy straggling effect are taken into account. On the basis of the calculated C-9-ion stopping distribution, it has been found that the area corresponding to the enhanced cell-killing effect of the C-9 beam appears at the stopping region of the incident C-9 ions. The stopping C-9-ion density in depth, then, is derived from the calculated probability density. Moreover, taking entrance dose 1 Gy for the C-9 beam as an example, the average stopping C-9-ion numbers per cell at various depths are deduced. Meanwhile, the mean lethal damage events induced by the C-9 and comparative C-12 beams at the depths with almost equal dose-averaged LETs are derived from the measured cell surviving fractions at these depths for the C-9 and C-12 beams. Under the condition of the same absorbed doses, there are indeed good agreements between the average stopping C-9-ion number pre cell and the difference of the mean lethal damage events between the C-9 and C-12 beams at the depths of similar dose-averaged LETs. It can be inferred that if a C-9 ion comes to rest in a cell, the cell would undergo dying. In view of the decay property of 9C nuclide, clustered damage would be caused in the cell by the emitted low-energy particles. Therefore, the results achieved in this work can be taken as indirect evidence supporting that damage cluster is more efficient in leading to cell lethality. |
| WOS关键词 | PARTICLE DECAY BEAM ; CANCER-THERAPY ; POTENTIAL APPLICATION ; IONIZING-RADIATIONS ; ION RADIOTHERAPY ; MAMMALIAN-CELLS ; LETHAL DAMAGE ; C-11 BEAMS ; HIMAC ; C-9 |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000234866000002 |
| 出版者 | SCIENCE PRESS |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/1003]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Li, Q |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Natl Inst Radiol Sci, Chiba 2638555, Japan |
| 推荐引用方式 GB/T 7714 | Kanazawa, M,Li, Q,Furusawa, Y,et al. Unraveling the mystery of enhanced cell-killing effect around the Bragg peak region of a double irradiation source C-9-ion beam[J]. CHINESE SCIENCE BULLETIN,2005,50(22):2546-2551. |
| APA | Kanazawa, M,Li, Q,Furusawa, Y,&Kitagawa, A.(2005).Unraveling the mystery of enhanced cell-killing effect around the Bragg peak region of a double irradiation source C-9-ion beam.CHINESE SCIENCE BULLETIN,50(22),2546-2551. |
| MLA | Kanazawa, M,et al."Unraveling the mystery of enhanced cell-killing effect around the Bragg peak region of a double irradiation source C-9-ion beam".CHINESE SCIENCE BULLETIN 50.22(2005):2546-2551. |
入库方式： OAI收割
来源：近代物理研究所
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