Biological effects of radioactive C-9-ion beams on cells
文献类型：期刊论文
| 作者 | Furusawa, Y; Urakabe, E; Xie, HM; Zhou, GM; Wei, ZQ; Li, Q ; Kitagawa, A; Kanai, T; Kanazawa, M
|
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2005-06-01 |
| 卷号 | 50期号:11页码:1070-1075 |
| 关键词 | radioactive ion beam parameter optimization cell survival effect RBE tumor treatment |
| ISSN号 | 1001-6538 |
| DOI | 10.1360/982004-774 |
| 英文摘要 | The distinguishing feature and current technique progress of tumor treatment with heavy-ion beams is introduced in the paper. Additional superiority to tumor treatment from a radioactive ion beam (RIB) is emphatically discussed. The experimental research of the radioactive C-9-ion beams aimed at tumor treatment at Heavy Ion Medical Accelerator in Chiba (HIMAC), National Institute of Radiological Sciences (NIRS), Japan is described in detail, including production of the beams, optimization of parameters, distribution of depth dose, survival effect of cell and comparison of RBE between C-9- and C-12-beams. Results show that under 40 mm thick Beryllium target and 10 turn thick aluminum degrader at full (5%) momentum acceptance, the production rate and purity of the produced C-9-beams are 9.07x10(-6) and 82.88% respectively with the primary (12)c- beams of 430 MeV/u and 1.8x10(9) pps. A uniform irradiation field with homogeneity up to 89.6% inside central area 10 mm in diameter is obtained by using spot scanning. In this case, the dose rate at the entrance is 0.5 Gy/h. In survival experiment of cells, the average relative biological effectiveness (RBE) of C-9-beams is 5.28 and 2.93 for C-12-beams in the region around Bragg peak. The RBE of C-9-beams is 1.8 times higher than that of C-12-beams. It indicates that cell-killing efficiency of 9C-beams is stronger than that of C-12-beams. C-9-beams are more efficacious for tumor treatment than C-12-beams. |
| WOS关键词 | HEAVY-ION RADIOTHERAPY ; THERAPY ; CANCER ; SYSTEM ; C-11 |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000231712400002 |
| 出版者 | SCIENCE PRESS |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/1071]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Wei, ZQ |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Natl Inst Radiol Sci, Chiba 2638555, Japan |
| 推荐引用方式 GB/T 7714 | Furusawa, Y,Urakabe, E,Xie, HM,et al. Biological effects of radioactive C-9-ion beams on cells[J]. CHINESE SCIENCE BULLETIN,2005,50(11):1070-1075. |
| APA | Furusawa, Y.,Urakabe, E.,Xie, HM.,Zhou, GM.,Wei, ZQ.,...&Kanazawa, M.(2005).Biological effects of radioactive C-9-ion beams on cells.CHINESE SCIENCE BULLETIN,50(11),1070-1075. |
| MLA | Furusawa, Y,et al."Biological effects of radioactive C-9-ion beams on cells".CHINESE SCIENCE BULLETIN 50.11(2005):1070-1075. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。