Therapeutic purpose C-9 beams produced in the secondary beam line at HIMAC
文献类型：期刊论文
| 作者 | Urakabe, E; Wei, Z; Sato, S; Tomitani, T; Kanazawa, M; Kanai, T; Kitagawa, A; Li, Q |
| 刊名 | NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
 |
| 出版日期 | 2004-07-01 |
| 卷号 | 222期号:6页码:270-284 |
| 关键词 | radioactive ion beam C-9 beam production rate purity momentum distribution irradiation field heavy-ion cancer therapy |
| ISSN号 | 0168-583X |
| DOI | 10.1016/j.nimb.2004.01.223 |
| 英文摘要 | Due to the favorable characteristics of heavy-ion beams such as dose localization as well as high relative biological effectiveness, heavy-ion cancer therapy is attracting growing interests all over the world. The application of P-delayed particle decay beams like C-9 ions in cancer therapy is expected to further improve the treatment efficacy of the modality of heavy-ions. For the first time C-9 beams were produced in the secondary beam line (SBL) of the HIMAC facility with a primary C-12 beam of 430 MeV/n. The production conditions providing a C-9 beam with higher production rate and purity were optimized using different thick production targets and degraders. The results show setting the momentum acceptance to the full value of 5% the production rate is 9.07 x 10(-6) and the purity is 82.88% for the produced C-9 beam under the optimal condition. Because of the large momentum spread for a secondary beam, the momentum distribution of the produced C-9 beam at the optimal condition was measured. The momentum among the beam had a nearly Gaussian profile with a standard deviation of 26.1 MeV/c/n and the largest component of the momenta appeared around 838.9 MeV/c/n. In order to form a relatively large uniform irradiation field being appropriate to further biological experiments for the produced C-9 beam, the scanning magnets in the irradiation system of the SBL, operating in a wobbling mode, was used. A uniform irradiation field of 20 mm in diameter could be achieved with homogeneity of 93.8%. The work presented in this paper provides a substantial basis for the further studies with 9C beams for the therapeutic purpose. (C) 2004 Elsevier B.V. All rights reserved. |
| WOS关键词 | HEAVY-ION RADIOTHERAPY ; IRRADIATION SYSTEM ; CANCER ; PARTICLES ; CELLS ; C-11 ; BASE |
| WOS研究方向 | Instruments & Instrumentation ; Nuclear Science & Technology ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000222062200031 |
| 出版者 | ELSEVIER SCIENCE BV |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/1861]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Li, Q |
| 作者单位 | 1.Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Dept Phys Med, Inage Ku, Chiba 2638555, Japan 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 3.Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Dept Accelerator Phys & Engn, Chiba 2638555, Japan |
| 推荐引用方式 GB/T 7714 | Urakabe, E,Wei, Z,Sato, S,et al. Therapeutic purpose C-9 beams produced in the secondary beam line at HIMAC[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,2004,222(6):270-284. |
| APA | Urakabe, E.,Wei, Z.,Sato, S.,Tomitani, T.,Kanazawa, M.,...&Li, Q.(2004).Therapeutic purpose C-9 beams produced in the secondary beam line at HIMAC.NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,222(6),270-284. |
| MLA | Urakabe, E,et al."Therapeutic purpose C-9 beams produced in the secondary beam line at HIMAC".NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 222.6(2004):270-284. |
入库方式： OAI收割
来源：近代物理研究所
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