Enhanced efficiency in cell killing at the penetration depths around the Bragg peak of a radioactive C-9-ion beam
文献类型：期刊论文
| 作者 | Aoki, M; Kanazawa, M; Li, Q ; Yoshimoto, M; Wei, ZQ; Sato, S; Tomitani, T; Urakabe, E; Kanai, T; Kitagawa, A
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| 刊名 | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
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| 出版日期 | 2005-11-15 |
| 卷号 | 63期号:4页码:1237-1244 |
| 关键词 | radioactive C-9-ion beam cell killing enhanced efficiency low dose rate cancer therapy |
| ISSN号 | 0360-3016 |
| DOI | 10.1016/j.ijrobp.2005.08.006 |
| 英文摘要 | Purpose: To evaluate the potential importance of radioactive C-9-ion beam in cancer radiotherapy. Methods and Materials: Human salivary gland (HSG) cells were exposed to a double-radiation-source C-9 beam at different depths around the Bragg peak. Cell survival fraction was determined by standard clonogenic assay. For comparison, the same experiment was conducted for a therapeutic C-12 beam. To determine relative biologic effectiveness (RBE) values, HSG cells were also irradiated with Co-60 gamma-rays of fractionation scheme as the reference. Results: The C-9 beam was more efficient in cell killing at the depths around its Bragg peak than was the C-12 beam, which corresponded to the C-9-ion stopping region and where delayed low-energy particles were emitted. The RBE value at 50% survival level for the C-9 beam varied from 1.38 to 4.23. Compared with the C-12 beam, the RBE values for the C-9 beam were always higher; an increase in RBE by a factor of up to 1.87 has been observed at the depths distal to the Bragg peak. Conclusion: The potential advantage of radioactive C-9-ion beam in cancer therapy has been revealed at low dose rate in comparison with a therapeutic 12 C beam. This observation, however, remains to be investigated at therapeutic dose rates in the future. (c) 2005 Elsevier Inc. |
| WOS关键词 | RELATIVE BIOLOGICAL EFFECTIVENESS ; DOUBLE-STRAND BREAKS ; CARBON ION RADIOTHERAPY ; PARTICLE DECAY BEAM ; LOW-ENERGY PROTONS ; IONIZING-RADIATIONS ; MAMMALIAN-CELLS ; ALPHA-PARTICLES ; TUMOR-CELLS ; V79 CELLS |
| WOS研究方向 | Oncology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000232943900035 |
| 出版者 | ELSEVIER SCIENCE INC |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/1909]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Li, Q |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 2.Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Chiba 260, Japan |
| 推荐引用方式 GB/T 7714 | Aoki, M,Kanazawa, M,Li, Q,et al. Enhanced efficiency in cell killing at the penetration depths around the Bragg peak of a radioactive C-9-ion beam[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2005,63(4):1237-1244. |
| APA | Aoki, M.,Kanazawa, M.,Li, Q.,Yoshimoto, M.,Wei, ZQ.,...&Furusawa, Y.(2005).Enhanced efficiency in cell killing at the penetration depths around the Bragg peak of a radioactive C-9-ion beam.INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,63(4),1237-1244. |
| MLA | Aoki, M,et al."Enhanced efficiency in cell killing at the penetration depths around the Bragg peak of a radioactive C-9-ion beam".INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 63.4(2005):1237-1244. |
入库方式： OAI收割
来源：近代物理研究所
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