The clonogenic surviving effect of human salivary gland cells exposed to high-linear energy transfer carbon ion beams at low dose rate
文献类型：期刊论文
| 作者 | Urakabe, E; Li, Q ; Furusawa, Y; Kanazawa, M; Aoki, M; Sato, S
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| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2005-09-01 |
| 卷号 | 32期号:9页码:895-899 |
| 关键词 | carbon ion beam dose rate high linear energy transfer(LET) dose surviving effect damage repair |
| ISSN号 | 1000-3282 |
| 英文摘要 | Human salivary gland cells (HSG) were irradiated with carbon ion beams supplied by the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan at a low dose rate of 0.5 Gy/h. Clonogenic survival effects of HSG cells after exposure to carbon beams with three different dose-averaged LETs were obtained by means of standard colony-forming assay. Compared to the previous surviving data acquired for carbon beams with similar dose-averaged LETs at therapeutic dose rates (1 similar to 5 Gy/min), HSG cells show an obvious dose-rate sparing effect. To derive relative biological effectiveness (RBE) of the carbon beams for HSG cells under the same dose-rate condition, the dose surviving effect of HSG cells irradiated with Co-60 gamma-rays was measured as well at the dose rate of 0.5 Gy/h. The RBE values obtained at the low dose rate are totally reduced in contrast with those determined at the preceding therapeutic dose rates. The dose-rate sparing effect and the reduction in RBE at the low dose rate imply that the radiation-induced damage by high-LET carbon ion beams at low dose rates could be repaired to a great extent. Based on the important findings, the essential reason of cell lethality by radiation was discussed. |
| WOS关键词 | RELATIVE BIOLOGICAL EFFECTIVENESS ; MAMMALIAN-CELLS ; RADIATION-DAMAGE ; ABERRATIONS ; MECHANISMS ; INDUCTION ; DEATH |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000232115500015 |
| 出版者 | SCIENCE PRESS |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/1927]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Li, Q |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Natl Inst Radiol Sci, Chiba 2638555, Japan |
| 推荐引用方式 GB/T 7714 | Urakabe, E,Li, Q,Furusawa, Y,et al. The clonogenic surviving effect of human salivary gland cells exposed to high-linear energy transfer carbon ion beams at low dose rate[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2005,32(9):895-899. |
| APA | Urakabe, E,Li, Q,Furusawa, Y,Kanazawa, M,Aoki, M,&Sato, S.(2005).The clonogenic surviving effect of human salivary gland cells exposed to high-linear energy transfer carbon ion beams at low dose rate.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,32(9),895-899. |
| MLA | Urakabe, E,et al."The clonogenic surviving effect of human salivary gland cells exposed to high-linear energy transfer carbon ion beams at low dose rate".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 32.9(2005):895-899. |
入库方式： OAI收割
来源：近代物理研究所
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